Evaluation of Captopril and Nifedipine in Treatment of Hypertension in Children with Post-streptoccal Acute Glomerulonephritis with Hypertension- A Randomized Control Trial

Phase 2

Recruiting

• Conditions: Control of Blood Pressure in Patients with Post-sterptococcal Acute Glomerulonephritis (PSAGN); Renal profiles in patients with Post-streptococcal Acute Glomerulonephritis (PSAGN); Cardiovascular - Hypertension; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12611000778987
• Lead Sponsor: niversiti Sains Malaysia (USM)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-07-26
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

All patients with clinical signs and symptoms PSAGN with hypertension (Blood Pressure of > 95 percentile of their respective height, age and gender) with the age between 1 year old to 12 years old, weight of 10 kg to 50 kg.
Clinical sign and symptoms of PSAGN includes history and clinical findings of facial puffiness and hematuria (urine RBC detected), decreased urine output or symptomatic hypertension. It preceded with history of impetigo or pharyngitis. Blood investigations includes complement levels, throat swab, positive ASOT or anti-DNAase.

Exclusion Criteria

1)Patients non post-streptococcal AGN i.e: SLE with Lupus Nephritis, Nephrotic syndrome, etc
2)Patients with PSAGN without hypertension (defined as BP > 95 percentile according to height, age and gender).
3)Encephalopathic patients defined as having seizures, severe headache and having fundoscopy changes that needs urgent antihypertensive or intravenous antihypertensives.
4)Second episode of PSAGN with hypertension.
5)Other causes of elevated BP i.e Essential Hypertension, Phaeochromocytoma
6)Patients with known renal problems

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the of blood pressure control in patients with PSAGN with hypertension in patients receiving Captopril and Nifedipine. This will be determine by normalization of blood pressure control by means of automated blood pressure measuring device.[During hospital admission until discharge];To compare the blood pressure control in patients with PSAGN with hypertension in patients receiving Captopril and Nifedipine by means of reading of blood pressure using ann automated blood pressure machine.[During hospital admission until discharge]