Captopril, spironolactone and carvedilol breast cancer
Phase 2
- Conditions
- Breast cancer.Malignant neoplasm of breast
- Registration Number
- IRCT2017061034432N1
- Lead Sponsor
- Vice-chancellor of research, Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
Women with breast cancer chemotherapy candidate; aged 30-70 years; having sinus rhythm; having echocardiography for LVEF (equal to or greater than 50%)
Exclusion criteria:
LVEF Less than 50%; previous myocardial infarction or known coronary artery disease; significant valvulopathy or cardiomyopathy (GFR <30 mm / min / 1.73m2); patients treated with ACEI, beta blocker, or ARB; drug sensitivity to ACEI, beta blocker, ARB; (SBP <90 mmHg and HR <60 beat / min); patients who currently have an AF rhythm and need treatment with class I antiarrhythmic drugs; pregnancy; dissatisfaction with participation in the research project; death
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean percent of flow-mediated vasodilatation (FMD) of Brachial artery. Timepoint: Before the chemotherapy, after the chemotherapy. Method of measurement: high resolution ultrasound.;Diastolic functional index. Timepoint: Before the chemotherapy, after the chemotherapy. Method of measurement: Echocardiography.;Mean percent of left ventricular ejection fraction (LVEF). Timepoint: Before the chemotherapy, after the chemotherapy. Method of measurement: Echocardiography.
- Secondary Outcome Measures
Name Time Method Blood urea nitrogen. Timepoint: Before starting the medication, two weeks after starting the medications, monthly. Method of measurement: Blood test.;Creatinine. Timepoint: Before starting the medication, two weeks after starting the medications, monthly. Method of measurement: Blood test.;Sodium. Timepoint: Before starting the medication, two weeks after starting the medications, monthly. Method of measurement: Blood test.;Potassium. Timepoint: Before starting the medication, two weeks after starting the medications, monthly. Method of measurement: Blood test.