Assessment of changes in metabolic activity in liver & skeletal muscle in patients suffering from acromegaly - a 31P/1H magnetic resonance spectroscopy pilot study - THIGHT_2

Medizinische Universität Wien, KIMIII, Abteilung für Endokrinologie und Stoffwechsel0 个研究点开始时间: 2014年2月25日最近更新: 2014年4月7日

适应症

试验速览

暂无简介。

•Patients suffering from Acromegaly:
•The diagnosis of acromegaly will be established by GH levels, not suppressible below 1 ng/ml after 75 g oral glucose tolerance test, and by high plasma IGF-I levels for age
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 22
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 4

•+ (known) overt diabetes mellitus
•+ known coronary artery disease (history of myocardial infarction or angina pectoris)
•+ acute or chronic (inflammatory, metabolic [hyperlipidemia, arterial hypertension, thyroid disorder]) disease (healthy controls)
•+ intake of medication potentially affecting glucose or lipid metabolism
•+ metal devices or other magnetic material in or on the subjects body which will be hazardous for NMR investigation [heart pacemaker, brain (aneurysm) clip, nerve stimulators, electrodes, ear implants, post coronary by-pass graft (epicardial pace wires), penile implants, colored contact lenses, patch to deliver medications through the skin, coiled spring intrauterine device, vascular filter for blood clots, orthodontic braces, shunt- spinal or ventricular, any metal implants (rods, joints, plates, pins, screws, nails, or clips without MR-authorization), embolization coil, or any metal fragments or shrapnel in the body].
•+ tendency toward claustrophobia
•+ severe liver disorders (plasma transaminases elevated > 3fold)
•+ any acute inflammatory disease within 2 weeks prior the study
•+ pregnancy
•+ Clinically relevant anemia

发起方

Medizinische Universität Wien, KIMIII, Abteilung für Endokrinologie und Stoffwechsel