EUCTR2013-004782-14-AT
Active, not recruiting
Not Applicable
Assessment of changes in metabolic activity in liver & skeletal muscle in patients suffering from acromegaly - a 31P/1H magnetic resonance spectroscopy pilot study - THIGHT_2
Medizinische Universität Wien, KIMIII, Abteilung für Endokrinologie und Stoffwechsel0 sitesFebruary 25, 2014
DrugsSomatuline Autogel
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acromegaly
- Sponsor
- Medizinische Universität Wien, KIMIII, Abteilung für Endokrinologie und Stoffwechsel
- Status
- Active, not recruiting
- Last Updated
- 12 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients suffering from Acromegaly:
- •The diagnosis of acromegaly will be established by GH levels, not suppressible below 1 ng/ml after 75 g oral glucose tolerance test, and by high plasma IGF\-I levels for age
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 22
- •F.1\.3 Elderly (\>\=65 years) yes
- •F.1\.3\.1 Number of subjects for this age range 4
Exclusion Criteria
- •\+ (known) overt diabetes mellitus
- •\+ known coronary artery disease (history of myocardial infarction or angina pectoris)
- •\+ acute or chronic (inflammatory, metabolic \[hyperlipidemia, arterial hypertension, thyroid disorder]) disease (healthy controls)
- •\+ intake of medication potentially affecting glucose or lipid metabolism
- •\+ metal devices or other magnetic material in or on the subjects body which will be hazardous for NMR investigation \[heart pacemaker, brain (aneurysm) clip, nerve stimulators, electrodes, ear implants, post coronary by\-pass graft (epicardial pace wires), penile implants, colored contact lenses, patch to deliver medications through the skin, coiled spring intrauterine device, vascular filter for blood clots, orthodontic braces, shunt\- spinal or ventricular, any metal implants (rods, joints, plates, pins, screws, nails, or clips without MR\-authorization), embolization coil, or any metal fragments or shrapnel in the body].
- •\+ tendency toward claustrophobia
- •\+ severe liver disorders (plasma transaminases elevated \> 3fold)
- •\+ any acute inflammatory disease within 2 weeks prior the study
- •\+ pregnancy
- •\+ Clinically relevant anemia
Outcomes
Primary Outcomes
Not specified
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