Postmenopausal women: training and natural protein supplementatio

Not Applicable

• Conditions: Consequences of menopause: weight gain, altered body composition, altered fat metabolism, altered bone metabolism.

• Registration Number: DRKS00024144
• Lead Sponsor: Deutsche Sporthochschule Köln, Institut für Kreislaufforschung und Sportmedizin, Abtl. Molekulare und zelluläre Sportmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-27
• Study Completion: 2021-12-15
• Results First Posted: 2023-03-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 64

Inclusion Criteria

postmenopausal women (50-65 years)
- at least 2 years after the last menstrual period
- willingness to use fitness tracker Polar Ignite and Polar Flow app

Exclusion Criteria

- > 2 times endurance training per week
- Unbalanced diets (e.g. vegan)
- Hormone substitution (incl. oral contraceptives)
- Hormonal diseases
- Psychiatric and / or addictive disorders
- Heart failure (EF <55)
- Metabolic diseases
- Cardiac arrhythmias requiring treatment
- Performance-limiting neurological diseases
- Performance-limiting renal disease
- Performance-limiting biliary disease
- Performance-limiting gastrointestinal diseases
- Performance-limiting pAVK (Fontaine stage = II)
- Performance-limiting muscular diseases
- Performance-limiting degenerative diseases
- Performance-limiting respiratory diseases
- History of performance-limiting oncological diseases (< 5 years)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Data will be collected at the start of the first training period, at the end of the first training period, and at the end of the second training period. Collected are: <br><br>by means of blood sampling<br>- estradiol<br>- progesterone<br>- FSH<br>- MYO before and after exercise<br>- Blood glucose before and after exercise<br>- HBa1c long-term blood glucose value <br>- HDL<br>- LDL<br>- triglycerides<br>- d44Ca/42Ca as proxy for bone metabolism<br><br>By means of a step test<br>- Individual anaerobic threshold<br>- Watts<br>- HR<br>- lactate<br>- 13C/12C in expired CO2<br>- d 13C/12C, Delta over Baseline (DOB)<br>- oxygen uptake<br>- Carbon dioxide output<br>- Respiratory quotient (RQ) <br>- Caloric equivalent <br><br>by morning urine<br>- d44Ca/42Ca as a proxy for bone metabolism <br><br>

Secondary Outcome Measures

Name	Time	Method
Data will be collected at the start of the first training period, at the end of the first training period, and at the end of the second training period. Collected are: <br>- Body height in cm<br>- weight in kg<br><br>by means of BIA:<br>- Body fat mass<br>- body cell mass<br>- body water<br>- lean mass<br>- muscle mass<br>- Extracellular mass<br><br>by means of strength testing:<br>- Leg press 5RM<br>- Chest press 5RM<br>- Grip strength 5RM <br><br>By means of Polar watch Ignite<br>- Number of steps per day<br>- Heart rate during training sessions <br>- Sleep behavior by means of sleep index<br><br>by questionnaire:<br>- Physical activity behavior