Développement Cognitif et cérébral Chez Les Adolescents Souffrants d'un Syndrome de Gilles de la Tourette
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Tourette Syndrome in Adolescence
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Enrollment
- 132
- Primary Endpoint
- Behavioral test main outcome measures [4]
- Last Updated
- 6 years ago
Overview
Brief Summary
In children with neurodevelopmental disorders, adolescence is usually associated with a reshaping of the clinical picture and symptomatology. Tourette syndrome (TS) is a paradigmal neurodevelopmental syndrome characterised by involuntary paroxysmal movements (motor tics) and vocalisation (vocal tics) often associated with various psychiatric disorders. The neuronal and cognitive mechanisms associated with TS symptoms improvement during adolescence, or the persistence in adulthood remains unknown, and this is what we aim to address in this study.
Detailed Description
Thus, the aims of the present project is threefold: Aim 1: To evaluate the maturation of cognitive functions in adolescents with TS compared to typically developing adolescents. To achieve this aim, three distinct cognitive dimensions will be assessed in all subjects (patients and controls): (i) reward sensitivity and habit formation; (ii) cognitive impulsivity and action control and (iii) self-agency. Aim 2: To identify neuronal correlates of cognitive function and brain development in health and disease. To achieve this aim, we will use a combined behavioural (as described in Aim 1), (i) neuroimaging and (ii) TMS approaches. Aim 3: To predict clinical outcome . In this part of the project we aim to identify behavioural, imaging or neurophysiological markers of clinical outcome in patients with TS.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Tourette syndrome
- •Ages 13 - 18
- •Acceptance to perform the Brain MRI
- •Acceptance to perform the cognitive testing
- •Acceptance to perform the TMS measures
Exclusion Criteria
- •Learning disability
- •Incompatibility with MRI procedure (metal body implants, pregnancy)
Outcomes
Primary Outcomes
Behavioral test main outcome measures [4]
Time Frame: from 16 to 20 months
agency composite scores
Behavioral test main outcome measures [2]
Time Frame: from 16 to 20 months
discounting factor
Behavioral test main outcome measures [3]
Time Frame: from 16 to 20 months
number of premature responses
Brain MRI scan measures
Time Frame: from 16 to 20 months
whole brain structural connectivity, whole brain functional connectivity, brain cortical and subcortical structures volumes and morphology
Behavioral test main outcome measures [1]
Time Frame: from 16 to 20 months
reaction times
Transcranial magnetic stimulation
Time Frame: from 16 to 20 months
intracortical inhibition (SICI) scores