Adolescent neurobiological predictors of developing psychosis
- Conditions
- psychosisschizophrenia10039628
- Registration Number
- NL-OMON36521
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 264
This is a follow-up study. Inclusion criteria will be the same as initial intake.
General inclusion criteria:
- For subjects who initially participated in the DUPS study: Age between 12 and 18 years at initial inclusion
- For new subjects: Aged between 12 and 24 years at initial inclusion (to allow us to supplement the DUPS sample)
Inclusion criteria for Ultra High Risk for Psychosis (UHR) Group:
- No previous psychotic episode for more than one week
- No clear organic etiological factor
- Voluntary participation (informed consent)
- Meets criteria for UHRP (page 19-21 of protocol)
Inclusion criteria for controls:
-No history of psychiatric disorder (axis 1, DSM-IV) according to diagnostic interview (DISC or SCAN)
-No history of psychotic disorder in first or second-degree family members
-Mental retardation (IQ < 70)
-Claustrophobia
-Presence of metal objects in or around the body
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measures are:<br /><br>(1) Cortical thickness, as assessed using a standard anatomical MRI scan<br /><br>(3D-FFE)<br /><br>(2) White matter integrity, as assessed using track-based FA measures from DTI </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary outcome measures are:<br /><br>(1) Volume of brain structures, as assessed using a standard anatomical MRI<br /><br>scan (3D-FFE)<br /><br>(2) Connectivity of resting state networks, as assessed with resting state fMRI<br /><br>(3) Genotype on candidate risk genes for psychosis</p><br>