Modifiable Predictors of Neural Vulnerabilities for Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 187
- 试验地点
- 1
- 主要终点
- Caudate Activation for Sip Cue
研究概览
简要总结
The purpose of this study is to examine patterns of neural activation in a priori selected brain regions associated with reward process during anticipation and delivery of appetizing food stimuli (milkshake sips) among young adults.
详细描述
This observational trial seeks to examine neural activation patterns in a food reward sensitivity task. The study uses the "milkshake" MRI task to assess individual food reward sensitivity in a sample of young adult participants. Participants are presented with a series of trials in which a visual cue is provided (either a glass of milkshake or water), followed by delivery of a sip of the corresponding liquid. Activation in a priori regions associated with reward processing is measured via blood oxygen level-dependent (BOLD) signal, both in response to the cue and actual delivery of the sip. Explicating patterns of reward processing for appetizing food stimuli holds potential to inform understanding of the neural underpinnings of obesity risk.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 19 years or older
- •Previous participation in the Preschool Problem Solving Study OR lived in Lancaster County, NE for at least part of high school
排除标准
- •Contraindications for functional magnetic resonance imaging (fMRI):
- •metal in body
- •pregnancy
- •non-removal piercings
- •hair extensions
- •As of 8/13/21, for individuals who were not in the Preschool Problem Solving Study but are invited to participate in the current study because they lived in Lancaster County for at least part of high school, the maximum age for eligibility is 20 years of age.
研究组 & 干预措施
fMRI
Participants are delivered sips of appetizing tastes (milkshake) and tasteless solution throughout the task while in the MRI scanner.
干预措施: Milkshake fMRI (Other)
结局指标
主要结局
Caudate Activation for Sip Cue
时间窗: 7 seconds after cue is presented
MRI blood oxygen level-dependent (BOLD) activity signal in the caudate for all milkshake cue trials versus all tasteless solution cue trials (milkshake\>tasteless) after receiving the cue but before the delivery of the actual sip.
Putamen Activation for Sip Cue
时间窗: 7 seconds after cue is presented
MRI blood oxygen level-dependent (BOLD) activity signal in the putamen for all milkshake cue trials versus all tasteless solution cue trials (milkshake\>tasteless) after receiving the cue but before the delivery of the actual sip.
Insula Activation for Sip Cue
时间窗: 7 seconds after cue is presented
MRI blood oxygen level-dependent (BOLD) activity signal in the insula for all milkshake cue trials versus all tasteless solution cue trials (milkshake\>tasteless) after receiving the cue but before the delivery of the actual sip.
Caudate Activation for Sip Delivery
时间窗: 7 seconds after delivery of sip
MRI blood oxygen level-dependent (BOLD) activity signal in the caudate for all milkshake trials versus all tasteless solution trials (milkshake\>tasteless) upon delivery of the actual sip.
Putamen Activation for Sip Delivery
时间窗: 7 seconds after delivery of sip
MRI blood oxygen level-dependent (BOLD) activity signal in the putamen for all milkshake trials versus all tasteless solution trials (milkshake\>tasteless) upon delivery of the actual sip.
Insula Activation for Sip Delivery
时间窗: 7 seconds after delivery of sip
MRI blood oxygen level-dependent (BOLD) activity signal in the insula for all milkshake trials versus all tasteless solution trials (milkshake\>tasteless) upon delivery of the actual sip.
次要结局
未报告次要终点