Effects of Treatments for Anemia and Iron Deficiency on the Electrolyte Balance in Lung Transplant Recipients: A Special Focus on Hypophosphatemia

Active, not recruiting

• Conditions: Hypophosphatemia

• Registration Number: NCT06112236
• Lead Sponsor: University of Zurich

Brief Summary

The aim of this study is to generate evidence regarding hypophosphatemia after iron infusion in lung transplant recipients in context of anemia and/or iron deficiency.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-17
• Study First Submitted: 2023-06-27
• Status Verified: 2023-10
• Study First Submitted QC: 2023-10-26
• Last Update Submitted: 2023-10-26
• Study First Posted: 2023-11-01
• Last Update Posted: 2023-11-01
• Primary Completion: 2026-12-31
• Study Completion: 2027-03-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• lung transplant recipient
• treated at the University Hospital Zurich between 2015 until 2022

Exclusion Criteria

• Denied general consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change of serum phosphate level	Baseline and up to 90 days after iron infusion	Change of serum phosphate level before and after iron infusion

Secondary Outcome Measures

Name	Time	Method
Change of urin phosphate level	Baseline and up to 90 days after iron infusion	Change of urin phosphate level before and after iron infusion
Change of serum albumin	Baseline and up to 90 days after iron infusion	Change of serum albumin level before and after iron infusion
Change of serum and urin calcium	Baseline and up to 90 days after iron infusion	Change of serum and urin calcium level before and after iron infusion
Complications after iron infusion	2015-2022	Number of patients with complications due to hypophosphatemia after iron infusion (Hospitalization, hypoxia, fracture due to hypophosphatemia)
Therapeutic management	2015 to 2022	Descriptive analysis of therapeutic management of hypophosphatemia after iron infusion
Change of mean corpuscular volume (MCV)	Baseline and up to 90 days after iron infusion	Changes of serum MCV level before and after iron infusion
Change of mean corpuscular hemoglobin (MCH)	Baseline and up to 90 days after iron infusion	Change of serum MCH level before and after iron infusion
Change of hemoglobin	Baseline and up to 90 days after iron infusion	Change of hemoglobin level before and after iron infusion
Change of serum magnesium	Baseline and up to 90 days after iron infusion	Change of serum magnesium level before and after iron infusion
Predictors	baseline and up to 90 days after iron infusion	Analysis of possible predictors for the decrease of serum phosphate levels after iron infusion

Trial Locations

Locations (1)

University Hospital Zurich; 🇨🇭 Zurich, Switzerland