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Clinical Trials/NCT02498730
NCT02498730
Completed
Not Applicable

Can the High Intensity Interval Training (HIIT) Deliver Superior and Rapid Decrease of Symptoms of Bipolar Disorder? a Controlled and Randomized Study

Universidade Federal do Rio de Janeiro1 site in 1 country36 target enrollmentAugust 2015

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Bipolar Disorder
Sponsor
Universidade Federal do Rio de Janeiro
Enrollment
36
Locations
1
Primary Endpoint
Symptom Scales (Hamilton and Young)
Status
Completed
Last Updated
3 years ago

Overview

Brief Summary

Our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as on the VO2max. In addition, the investigators will establish what influence of gain to VO2max has on reducing symptoms.

Detailed Description

Physical exercise has significant effects on health promotion and the consequent reduction of the severity of bipolar disorder (BD). This review establishes a pattern of response of exercise and potential impact on the pathophysiology of BD; , as well as, produces hypotheses on how acute and chronic effect of exercises may act differently; and provides future perspectives with the focus of the exercise as an important and innovative model of treatment for BD and mental disorder. A critical evaluation of the literature was undertaken including the influence of exercise on health promotion in patients with mental disorders, neurochemical behavior exercise-induced, as well as reflective introduction of news perspectives of training control in severe exercise domain. The exercise induces significant changes in monoaminergic after, and with long-term training, and work with a threshold of exercise can modulate positive effects on mood. Fast adaptive effects from the high intensity interval training should be considered in BD patients. However, there must be caution in his administration. We speculate that exercise may be a way of maintaining euthymia in the case of BD, making it less vulnerable patient to stay longer at a time of neutrality. Future research is needed to adopt a training strategy that is both time efficient in the different areas and adequate for the population in question.

Registry
clinicaltrials.gov
Start Date
August 2015
End Date
July 2017
Last Updated
3 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Alberto Souza de Sá Filho

Doctorade in Mental Health

Universidade Federal do Rio de Janeiro

Eligibility Criteria

Inclusion Criteria

  • Bipolar Criteria (DSM-IV),
  • sedentary lifestyle

Exclusion Criteria

  • 60 and over,
  • Cardiovascular Disease,
  • Panic disorder,
  • Metabolic syndrome Diagnosis

Outcomes

Primary Outcomes

Symptom Scales (Hamilton and Young)

Time Frame: 0 week, 6 week, 12 week

Variable Measured to reduction of symptoms

Secondary Outcomes

  • Cortical Changes (EEG) - Loreta(0 week, 6 week, 12 week)
  • Cognitive Function(0 week, 6 week, 12 week)
  • VO2Max(0 week, 6 week, 12 week)

Study Sites (1)

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