Oral Thyroid hormone In Healthy volunteers Study: an interventional study on the effect of thyroid hormone on coagulation and fibrinolytic parameters.

• Conditions: coagulation system; excess of thyroid hormone; hemostasis; hyperthyroidism; 10064477; 10043739

• Registration Number: NL-OMON31212
• Lead Sponsor: Slotervaartziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

- Adult >= 18 years and <= 40 years old.
- Informed consent.

Exclusion Criteria

- Long term drug therapy including use or oral anticonceptive agents.
- Ongoing febrile, inflammatory, cardiovascular, renal, pulmonary, liver, neurological, endocrine, neoplastic diseases.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Coagulation and fibrinolytic parameters:<br /><br>1) Prothrombin fragment 1+2 (F1+2)<br /><br>2) Von Willebrand factor antigen (vWfAg)<br /><br>3) D-dimer (ELISA assay)<br /><br>4) Prothrombin time (PT)<br /><br>5) Activated partial thromboplastin time (aPTT)<br /><br>6) von Willebrand factor activity<br /><br>7) factor VIII:C<br /><br>8) Plasmin-antiplasmin complex (PAP)<br /><br>9) Thrombin generation test (ETP)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Lipid parameters:<br /><br>1) Total cholesterol<br /><br>2) Low density lipoprotein (LDL)<br /><br>3) High density lipoprotein (HDL)<br /><br>4) Lipoprotein (a) (Lp(a))<br /><br>5) Apolipoprotein A-I (Apo A-I)<br /><br>6) Apolipoprotein B (Apo B)<br /><br>7) CRP (C-Reactive protein)</p><br>