Effects of NAVA on diaphragm functio
- Conditions
- Health Condition 1: J471- Bronchiectasis with (acute) exacerbationHealth Condition 2: J441- Chronic obstructive pulmonary disease with (acute) exacerbationHealth Condition 3: J439- Emphysema, unspecifiedHealth Condition 4: J459- Other and unspecified asthmaHealth Condition 5: J848- Other specified interstitial pulmonary diseasesHealth Condition 6: J42- Unspecified chronic bronchitis
- Registration Number
- CTRI/2019/05/019018
- Lead Sponsor
- Department of Pulmonary Critical Care and Sleep Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. All adult patient (age more than or equal to 18 years) presenting with respiratory failure requiring invasive mechanical ventilation.
2. Patients able to spontaneously trigger the ventilator
1. Unable to trigger ventilator
2. Moderate or severe acute respiratory distress syndrome (ARDS)
3. Presence of three or more organ system failures
4. Neurological or neuromuscular disease(CVA,GBS,Mysthaeniaetc)
5. Known Phrenic nerve palsy
6. Patient who cannot be ventilated without neuromuscular blockers
7. Patient in shock requiring 2 or more inotropes
8. Any contraindication to the insertion of a nasogastric tube (for example: recent upper gastrointestinal surgery, esophageal varices).
9. Patients on mechanical ventilation for more than 3 days.
10. Patient not willing to participate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the incidence of diaphragmatic dysfunction (defined as diaphragm thickness fraction less than 20%) in patient ventilated with NAVA as compared to conventional mechanical ventilation.Timepoint: Day 5 or Day of Extubation whichever is earlier
- Secondary Outcome Measures
Name Time Method 1. Change in thickness of Diaphragm <br/ ><br>2. Diaphragmatic excursion <br/ ><br>3. Diaphragmatic efficiency (NVE and NME) <br/ ><br>Timepoint: Day 5 or Day of Extubation which ever is earlier