NL-OMON44546已完成3 期
The effect of high-resistance muscle strength training and vitamin D supplementation in persons with knee osteoarthritis - VitD-EX
Jan van Breemen Instituut0 个研究点目标入组 288 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 288
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Knee pain and at least 2 of the following 5 items: morning stiffness <
- •30 minutes, crepitations, bone sensitivity, bony enlargement of the joint
- •margin, no palpable warmth
- •- Age >= 55 and <= 80 years
- •- Vitamin D deficiency: 25(OH)D level >15nmol/L and <50 nmol/L (in
- •winter) or <70nmol/L (in summer);In addition, 68 knee OA patients with normal vitamin D levels will be included in order to study the effect of high versus low resistance strength training. The larger sample size (n=288) will lead to more statistical power. Patients with normal vitamin D levels will be randomized into either high or low resistance training, without supplementation with vitamin D or placebo.
排除标准
- •- Other forms of arthritis than OA
- •- Absolute contra-indication for exercise therapy/strength training
- •- Inability to perform strength training program due to severe comorbidity
- •- Use of vitamin D supplements >800 IU daily
- •- Living in a nursing home
研究者
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