Novel Treatment Targets For Affective Disorders Through Cross-Species Investigation of Approach/Avoidance Decision Making
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Major Depression in Remission
- Sponsor
- Mclean Hospital
- Enrollment
- 148
- Locations
- 1
- Primary Endpoint
- Clinical Interview
- Status
- Active, not recruiting
- Last Updated
- 4 months ago
Overview
Brief Summary
This study investigates how remitted individuals with past major depressive disorder (MDD) make approach-avoidance decisions and which brain regions are implicated in such decisions. Information collected through MRI and behavioral tasks will be used to predict depressive symptoms in the future.
Detailed Description
The overarching goals of this research are to investigate: (1) neural substrates of approach/avoidance behaviors in remitted MDDs; (2) stress-induced signaling in remitted individuals with past MDD; (3) neural markers that prospectively predict disease course. This will be achieved through an innovative method of using functional magnetic resonance imaging (fMRI) during an approach/avoidance decision-making task.
Investigators
Diego Pizzagalli
Principal Investigator; Professor, Department of Psychiatry, Harvard Medical School, Mclean Hospital
Mclean Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Clinical Interview
Time Frame: Baseline
For assessing psychological state
Salivary Cortisol
Time Frame: Baseline
For assessing stress level
MRI Data
Time Frame: MRI scans take place within 30 days of Screening Visit
For testing the neural correlates of approach-avoidance decision making behaviors in a trans-diagnostic sample
Follow-up Clinical interviews
Time Frame: Change from Baseline at 6 months and 12 months after the MRI scanning visit
To assess psychological state changes
Behavioral Performance on the Probabilistic Reward Task (PRT)
Time Frame: Baseline
The Probablilistic Reward Task assesses positive reinforcement learning.