Novel Treatment Targets For Affective Disorders Through Cross-Species Investigation of Approach/Avoidance Decision Making
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 148
- 试验地点
- 1
- 主要终点
- Clinical Interview
研究概览
简要总结
This study investigates how remitted individuals with past major depressive disorder (MDD) make approach-avoidance decisions and which brain regions are implicated in such decisions. Information collected through MRI and behavioral tasks will be used to predict depressive symptoms in the future.
详细描述
The overarching goals of this research are to investigate: (1) neural substrates of approach/avoidance behaviors in remitted MDDs; (2) stress-induced signaling in remitted individuals with past MDD; (3) neural markers that prospectively predict disease course.
This will be achieved through an innovative method of using functional magnetic resonance imaging (fMRI) during an approach/avoidance decision-making task.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Clinical Interview
时间窗: Baseline
For assessing psychological state
Salivary Cortisol
时间窗: Baseline
For assessing stress level
MRI Data
时间窗: MRI scans take place within 30 days of Screening Visit
For testing the neural correlates of approach-avoidance decision making behaviors in a trans-diagnostic sample
Follow-up Clinical interviews
时间窗: Change from Baseline at 6 months and 12 months after the MRI scanning visit
To assess psychological state changes
Behavioral Performance on the Probabilistic Reward Task (PRT)
时间窗: Baseline
The Probablilistic Reward Task assesses positive reinforcement learning.
次要结局
未报告次要终点
研究者
Diego Pizzagalli
Principal Investigator; Professor, Department of Psychiatry, Harvard Medical School, Mclean Hospital
Mclean Hospital