Role of Advanced MRI Sequences in Differentiating MS and Its Mimics
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Assiut University
- Enrollment
- 70
- Primary Endpoint
- role of advanced MRI sequences in establishing the diagnosis of multiple sclerosis(MS)
- Last Updated
- 7 years ago
Overview
Brief Summary
We aim to evaluate the role of conventional and advanced MRI sequences in:
- Establishing the diagnosis of multiple sclerosis and differentiate it from its mimics.
- Predict the prognosis and evaluate the treatment response in the first year of patients with multiple sclerosis.
Detailed Description
All patients in the study will be referred among those attend to Assuit university hospital with clinical symptoms suspicious of MS according to McDonald criteria 2017 with age range from (18-50 years old). MRI study will be done for each patient. MRI study will be repeated for those already diagnosed as MS after starting the suitable treatment as decided by attending physician after one year to assess the efficacy of treatment and the patient prognosis. MR imaging will be performed on a 1.5-T MR imaging unit (Siemens, Sembra medical system,German). Prospectively completed data forms will be analyzed and compared. Statistical tests appropriate to the nature of the data will be used. All patients will not be subjected to risk of any kind during this study. All patients' data will be confidentially kept. Approval of the ethical committee of Faculty of Medicine, Assiut University. An informed consent will be taken from all patients included in this study. * The research will be conducted only by scientifically qualified and trained personnel. * The procedures included in this study have been already used in hospital and centers in and outside Egypt.
Investigators
Samaa Mostafa El-kossi
assisstant lecturer
Assiut University
Eligibility Criteria
Inclusion Criteria
- •All patients in the study will be referred among those attend to Assuit university hospital with clinical symptoms suspicious of MS according to McDonald criteria 2017 with age range from (18-50 years old).
Exclusion Criteria
- •o Any general contraindication of MRI in some cases as presence of paramagnetic substance as pacemakers or in patients with claustrophobia.
- •Patient above 50 years old.
Outcomes
Primary Outcomes
role of advanced MRI sequences in establishing the diagnosis of multiple sclerosis(MS)
Time Frame: baseline
calculating the sensitivity,specificity and accuracy of diffusion tensor imaging (DTI) and dual inversion recovery(DIR) in differentiating MS from its mimics
Secondary Outcomes
- follow up of MS patients after one year of treatment(one year)