Role of Advanced Magnetic Resonance Imaging in Diagnosis of Idiopathic Temporal Lobe Epilepsy
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Calculating the sensitivity,specificity and accuracy of hippocampal volumetry , T2 relaxometry , MR spectroscopy and diffusion tensor imaging in identification and lataeralization of epileptogenic focus
研究概览
简要总结
We aim to o evaluate the role of conventional and advanced MRI sequences in diagnosis of idiopathic temporal lobe epilepsy including identification and lateralization of epileptogenic focus.
详细描述
Patients with history of partial seizures with or without secondary generalization attending at outpatient clinic or admitted at Neurology department of Assuit University Hospital will be included in the study MRI study will be done for each patient. MR imaging will be performed on a 1.5-T MR imaging unit (Siemens, Sembra medical system,German).
Prospectively completed data forms will be analyzed and compared. Statistical tests appropriate to the nature of the data will be used.
All patients will not be subjected to risk of any kind during this study. All patients' data will be confidentially kept. Approval of the ethical committee of Faculty of Medicine, Assiut University.
An informed consent will be taken from all patients included in this study. The research will be conducted only by scientifically qualified and trained personnel.
The procedures included in this study have been already used in hospital and centers in and outside Egypt
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with history of partial seizures with or without secondary generalization attending at outpatient clinic or admitted at Neurology department of Assuit University Hospital will be included in the study based on the following criteria:
- •Clinical features consistent with seizures of temporal lobe origin.
- •Focal ictal temporal lobe patterns recorded with EEG.
- •No lesion detected by conventional MR imaging other than mesial temporal sclerosis.
排除标准
- •Any general contraindication of MRI in some cases as presence of para magnetic substance as pacemakers or in patients with claustrophobia.
- •Subjects with age less than 12 year old.
- •Patients with any structural lesion other than mesial temporal sclerosis identified on MR brain imaging.
结局指标
主要结局
Calculating the sensitivity,specificity and accuracy of hippocampal volumetry , T2 relaxometry , MR spectroscopy and diffusion tensor imaging in identification and lataeralization of epileptogenic focus
时间窗: baseline
* Quantification of hippocampal volumes bilaterally by mean of hippocampal volumetry * Change in metabolites ratio at the affected hippocampus by mean of MR spectroscopy
次要结局
未报告次要终点
研究者
Radwa Anas Abou El-Kasem
Assistant lecturer
Assiut University