NL-OMON51937
Not yet recruiting
Not Applicable
Magnetic resonance imaging for phenotyping and accurate Monitoring of Interstitial Lung Disease: the M-ILD study - M-ILD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Interstitiele longziekten (Interstitial Lung Disease, ILD)
- Sponsor
- Erasmus MC, Universitair Medisch Centrum Rotterdam
- Enrollment
- 60
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Multidisciplinary diagnosis of PF\-ILD (progressive fibrotic ILD group
- •including IPF) OR inflammatory ILD (including idiopathic NSIP, ILD related to
- •connective tissue disease or with autoimmune features or chronic
- •hypersensitivity pneumonitis (IGr).
- •\- Informed consent
- •\- About to start treatment for their ILD. Each patient will be treated as
- •decided in the MDT according to standard clinical practice. PF\-ILD and IPF
- •group are usually treated with anti\-fibrotic drugs (nintedanib or pirfenidone).
- •The I\-ILD group are treated with anti\-inflammatory therapy, such as prednisone,
- •mycophenolate mofetil, azathioprine, rituximab.
Exclusion Criteria
- •\- Contra\-indications or inability to undergo MRI (i.e. claustrophobia.)
- •\- Current lung infection (according to treating physician)
- •\- Respiratory distress at rest despite oxygen
- •\- Contra\-indication to use gadolinium contrast (severe renal insufficiency,
- •estimated glomerular filtration rate \[eGFR] \<30 mL/min per 1\.73 m2\)(28\)
- •\- Previous allergic reaction to gadolinium or iodinated contrast media
- •\- Acute ILD exacerbations at baseline
- •\- High flow chronic oxygen need(respiratory distress at rest despite oxygen)
- •\- Lung cancer at baseline
- •\- For PF\-ILD group: previous treatment with anti\-fibrotic medications
Outcomes
Primary Outcomes
Not specified
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