ISRCTN62033854
Completed
未知
Magnetic resonance imaging to characterise invasive phenotypes in cerebral gliomas: an observational prospective cohort study
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Glioblastomas
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust (UK)
- Enrollment
- 145
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Imaging appearances of a high grade glioma
- •2\. Likely to be suitable for radiotherapy (60 Gy) with concomitant and adjuvant temozolomide
- •3\. World Health Organization (WHO) performance status (PS) grade 0 or 2
- •4\. Aged 18 \- 75 years, either sex
- •5\. Resection or biopsy (although only those suitable for maximal resection will be considered for the MALTING Trial)
- •Patients for the MALTING Trial will be felt by their consultant neurosurgeon to be suitable for 5\-aminolevulinic acid (5\-ALA) fluorescence\-guided resection with insertion of carmustine wafers.
Exclusion Criteria
- •1\. Unsuitable for a contrast\-enhanced MRI (MR unsafe metallic implants, claustrophobia, allergy to gadolinium contrast agent or severe renal impairment)
- •2\. Pregnant
- •3\. Allergic to aminolevulinic acid
- •4\. Suffering from porphyria. Care will be taken if the patient is taking other photosensitising drugs.
Outcomes
Primary Outcomes
Not specified
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