Magnetic Resonance Imaging and Ultrasound Imaging of Peripheral Nerves in Patients Treated With Immunoglobulin in Chronic Inflammatory Demyelinating Polyradiculoneuropathy.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Inflammatory Demyelinating Polyradiculoneuropathy
- Sponsor
- University of Aarhus
- Enrollment
- 39
- Locations
- 1
- Primary Endpoint
- DTI changes in nerves and muscles
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
We want to study whether MRI can be useful in diagnosing and monitoring patients with CIDP in maintenance treatment with immunoglobulin
Detailed Description
Chronic inflammatory neuropathies such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) can be successfully treated with immunoglobulin either intravenously (IVIG) or subcutaneously (SCIG). CIDP is diagnosed by electrophysiology which is time-consuming and unpleasant for the patient. New techniques suggest that Magnetic Resonance Imaging (MRI) and ultrasound imaging can be used to detect injuries in the peripheral nerves We want to study if MRI and ultrasound is able to detect damages in peripheral nerves, nerve roots and plexus in patients with CIDP. Moreover, we want to compare these findings to healthy matched controls and to see if treatment with immunoglobulin changes findings in MRI
Investigators
Eligibility Criteria
Inclusion Criteria
- •CIDP patients
- •Age \> 18 and \< 80 years
- •Diagnosed with definite and probable CIDP and fulfilling the European Federation of Neurological Sciences/Peripheral Nerve Society (EFNS/PNS) criteria
- •Healthy controls
- •Age \> 18 and \< 80 years
- •No neurological disorders
Exclusion Criteria
- •Age \< 18 or \> 80 years
- •Contraindications to MRI
- •Pregnancy
- •Other cause of neuropathy (incl. pressure neuropathy)
- •Diabetes mellitus
Outcomes
Primary Outcomes
DTI changes in nerves and muscles
Time Frame: At enrolment
Diffusion Tension Imaging (DTI) in peripheral nerves and muscles in the lower extremities in CIDP patients treated with SCIG will be compared to healthy controls
Secondary Outcomes
- Comparing clinical findings to MRI(At enrolment)
- Changes in MRI findings between treated and untreated CIDP patients(All patients are examined at enrolment. Untreated patients are re-examined after 4 months of treatment)