Safety and usefulness of application of direct painless electrical current to brain in patients with pseudo seizure.
- Conditions
- Health Condition 1: F445- Conversion disorder with seizuresor convulsions
- Registration Number
- CTRI/2020/09/027669
- Lead Sponsor
- JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION amp RESEARCH PUDUCHERRY
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Our study include two sets of patients i.e
1.clinically established PNES &;
2.Documented PNES,
having aged >18 years and >=2 events/month.
According to ILAE (International League Against Epilepsy),
Clinically Established PNES:These are those patients, who are diagnosed by an experienced clinician(in seizure disorder) on the basis of video or person that showing semiology typical of PNES.
Documented PNES are those patients diagnosed by experienced clinician on the basis of semiology typical of PNES in video EEG.
1.Subjects with known epilepsy
2.Subjects with PNES who have significant intellectual disability
3.Severe psychiatric comorbidity and suicidal ideations
4.Pregnant women
5.Those with dementia, psychosis, delirium, scalp infections or lesions
6.Subjects with history of brain surgery or aneurysm clipping or electrical device implantation like pacemaker
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the efficacy of transcranial direct current stimulation compared to sham stimulation in increasing the proportion of subjects achieving â?¥50% reduction in event frequency/month at the end of 1st month of treatment compared to baseline in subjects with psychogenic non epileptic seizuresTimepoint: 1 month
- Secondary Outcome Measures
Name Time Method 1.To determine the safety of tDCS in this subject population. <br/ ><br>2.To determine if the effects of tDCS on event frequency at the end of 2nd and 3rd month after treatment. <br/ ><br>3.To determine effects of tDCS on measures of psychopathology (HAM-A and HAM-D) and quality of life measures (WHO BREF-QOL and QOLIE) <br/ ><br>4.To explore factors associated with response to tDCS such as imaging abnormalities <br/ ><br>5.To see the effect of tDCS on the EEG power spectrum <br/ ><br>Timepoint: 2nd & 3rd month