Effect of Mediterranean diet components on microbiota
Not Applicable
- Conditions
- Overweight and low adherence to the Mediterranean DietNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN20979777
- Lead Sponsor
- Ministry of Education, Universities and Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 125
Inclusion Criteria
1. Age 30 - 60 years old
2. BMI 25 - 29.9 kg/m²
3. Low adherence (score = 5) to the Mediterranean diet
Exclusion Criteria
1. Obesity (BMI <25 or >30 kg/m²)
2. Diabetes, dysthyroidism
3. Chronic constipation, diarrhea or any other gut disease
4. Liver, kidney or other diseases
5. Known food allergies
6. Regular use of medications, dietary supplement
7. Consumption of antibiotics in the previous 3 months
8. Specific diet such as vegan or macrobiotic
9. Pregnancy/lactation
10. SARS-CoV-2 infection diagnosed by molecular diagnostic
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fecal Prevotella relative amount analysed by high-throughput rRNA gene-targeted amplicon sequencing and short-chain fatty acids (SCFAs), urinary and fecal ferulic acid analysed by GC-MS and 1H-NMR at time zero and after 8 weeks
- Secondary Outcome Measures
Name Time Method