Formulations containing nisin and/or dextranase enzyme against cariogenic and periodontopathic microorganisms

Phase 1

Completed

• Conditions: Gingivitis; There are 3 groups.1. Dental caries volunteers2. Gingivitis or normal volunteers3. Periodontal volunteers; Dental caries; Periodontal

• Registration Number: TCTR20190927005
• Lead Sponsor: Faculty of Pharmacy

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-06-17
• Study Start: 2019-09-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

1. No smoking
2. The volunteers do not use aspirin, heparin, steroidal antibiotic before joining the project 14 days.

Exclusion Criteria

1.Volunteers have systemic diseases such as diabetes, heart, etc.
2.Volunteers have diseases about blood such as abnormalities in the tube wall blood and platelets, Hemophilia, Won etc.
3.Volunteers have tissue disease in teeth or dead teeth
4.Volunteers are pregnant

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The oral pathogen bacteria at 0 and 4 weeks The Changing in oral pathogenic bacteria

Secondary Outcome Measures

Name	Time	Method
Plaque index at 0 and 4 weeks Plaque score,Bleeding on probe at 0 and 4 weeks Bleeding,Probing depth at 0 and 4 weeks Probing depth score,Gingival index at 0 and 4 weeks Gingival score