Embryo Selection Using Non-invasive Metabolomic Analysis Versus Morphology

Phase 4

Completed

• Conditions: Embryo Viability
• Interventions: Other: morphological evaluation; Procedure: non-invasive metabolomic profiling

• Registration Number: NCT01490515
• Lead Sponsor: Eugonia

Brief Summary

Metabolomics was recently introduced in human IVF for non-invasive identification of viable embryos with the highest developmental competence. The investigators intended to investigate if embryo assessment using non-invasive metabolomic profiling leads to increased implantation rates compared to routine morphology evaluation alone.

Detailed Description

Metabolomics was recently introduced in human IVF for non-invasive identification of viable embryos with the highest developmental competence. The aim of the present study was to determine whether embryo selection using non-invasive metabolomic profiling as an adjunct to morphology leads to increased implantation rates compared to routine morphology evaluation alone.

Study Timeline

• Study Start: 2010-04
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Status Verified: 2011-12
• Study First Submitted: 2011-12-09
• Study First Submitted QC: 2011-12-12
• Study First Posted: 2011-12-13
• Last Update Submitted: 2013-12-13
• Last Update Posted: 2013-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 125

Inclusion Criteria

• patients with at least 4 fertilized oocytes

Exclusion Criteria

• patients with less that 4 fertilized oocytes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Morphology embryo evaluation	morphological evaluation	To compare non-invasive metabolomic profiling and the traditional method of morphology assessment for embryo selection in terms of implantation and pregnancy rates in a clinical IVF program.
non-invasive metabolomic profiling	non-invasive metabolomic profiling	To compare non-invasive metabolomic profiling and the traditional method of morphology assessment for embryo selection in terms of implantation and pregnancy rates in a clinical IVF program.

Primary Outcome Measures

Name	Time	Method
Implantation rates	6 weeks of pregnancy	To compare non-invasive metabolomic profiling and the traditional method of morphology assessment for embryo selection in terms of implantation and pregnancy rates in a clinical IVF program.

Trial Locations

Locations (1)

Eugonia ART Unit; 🇬🇷 Athens, Attiki, Greece