Embryo selection by metabolomic profiling.

Completed

• Conditions: 1. Metabolomic profiling; <br />2. embryo selection; <br />3. IVF; <br />4. single embryo transfer (SET).

• Registration Number: NL-OMON20735
• Lead Sponsor: VU University medical centerDivision of reproductive medicine

Brief Summary

Day 3 embryo selection by metabolomic profiling of culture medium with near-infrared spectroscopy as an adjunct to morphology: a randomized controlled trial. Vergouw CG, Kieslinger DC, Kostelijk EH, Botros LL, Schats R, Hompes PG, Sakkas D, Lambalk CB. Hum Reprod. 2012 Aug;27(8):2304-11. doi: 10.1093/humrep/des175. Epub 2012 May 30. <br> <br> No evidence that embryo selection by near-infrared spectroscopy in addition to morphology is able to improve live birth rates: results from an individual patient data meta-analysis. Vergouw CG, Heymans MW, Hardarson T, Sfontouris IA, Economou KA, Ahlström A, Rogberg L, Lainas TG, Sakkas D, Kieslinger DC, Kostelijk EH, Hompes PG, Schats R, Lambalk CB. Hum Reprod. 2014 Mar;29(3):455-61. doi: 10.1093/humrep/det456. Epub 2014 Jan 8.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 370

Inclusion Criteria

Patients with SET, at least two embryos of equal quality.

Exclusion Criteria

1. Patients with DET (double embryo transfer);

2. patients with less than 2 embryos of equal quality;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ife birth rate.

Secondary Outcome Measures

Name	Time	Method
Ongoing pregnancy rate. Ongoing pregnancy is defined as a positive fetal heart beat at 12 weeks gestational age.