Therapy individualisation for patients with acute respiratory distress syndrome according to blood flow
Completed
- Conditions
- Acute respiratory distress syndrome (ARDS)Respiratory
- Registration Number
- ISRCTN12607675
- Lead Sponsor
- II. Medical Department, Klinikum rechts der Isar, Technische Universtität München
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 14
Inclusion Criteria
1. Aged 18 or older
2. Critically ill
3. Severe acute respiratory distress syndrome (ARDS)
4. Extracorporeal membrane oxgenation
5. Trans-pulmonary thermodilution monitoring
Exclusion Criteria
1. Pregnant
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in global end diastolic volume index (GEDVI), extravascular lung water index (EVLWI) and cardiac output (CO), assessed using transpulmonary thermodilution:<br>1. Between patients with jugular and femoral central venous catheter (CVC) before the initiation of extracorporeal membrane oxygenation (ECMO)<br>2. Before and during ECMO within groups of patients with jugular and femoral indicator injection
- Secondary Outcome Measures
Name Time Method The following are assessed using transpulmonary thermodilution (TPTD) and pulse contour analysis (PCA) 8 hours prior to initiation of ECMO, immediately prior to ECMO, immediately after initiation of ECMO and around 8 hours after ECMO:<br>1. Comparison of the final ECMO-flow for patients with jugular and femoral group.<br>2. Comparison of the next-to-last measurements before ECMO and the second TPTDs under the target ECMO-flow.<br>3. Comparison of the differences of TPTD-values before and during ECMO between the groups with jugular and femoral indicator injection. <br>4. Analyzing the change in TPTD-values induced by the extracorporeal circuit by multiple regression analysis.<br><br> <br>