A randomized placebo-controlled trial about the effect of UVB-irradiated white button mushrooms (Agaricus bisporus) and a vitamin D2 supplement on the 25(OH)D levels in healthy adults.
Not Applicable
Completed
- Conditions
- healthy adults with vitamin D deficiencyE56.9Vitamin deficiency, unspecified
- Registration Number
- DRKS00000195
- Lead Sponsor
- Medizinische Universitätsklinik Freiburg - Abteilung Innere Medizin IHämatologie und Onkologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
healthy general condition based on medical history and examination at admission
- body mass index (BMI) between 18,5 and 26 kg/m²
- serum 25(OH)D < 25 ng/ml (< 50 nM)
- serum calcium in normal range 2,15 ? 2,55 mM
- written informed consent of the participants after educational advertising
Exclusion Criteria
- anamnesis of kidney stone
- pregnancy
- white button mushrooms intolerance or allergy
- visit of a tanning salon right before or during the study
- eating fish or liver during the study
- taking supplements of Vitamin D during the study
- abidance in the mountains or southern countries during the study
- serum calcium > 5,2 mM during the study
- cancellation of the informed consent
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Significant rising of the serum 25(OH)D level from young healthy adults by the consumption of UV-B treated mushrooms compared to non-treated mushrooms. Serum 25(OH)D level will be measured 4 times on each weekly encounter and 1 time a week after the last soup administration.
- Secondary Outcome Measures
Name Time Method Equality of UV-B treated mushrooms compared to a normal Vitamin D2 supplement in regard to improve the 25(OH)D status. The 25(OH)D status will be measured at the five weekly encounters.