EUCTR2006-004846-17-GB进行中（未招募）不适用
A randomised, placebo controlled trial of the efficacy of the addition of spironolactone to modern antihypertensive treatment regimes in patients with resistant hypertension.
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Aged>18 years.
- •Hypertension (essential or secondary) managed in Sheffield Hypertension Clinic or General Practice or both.
- •Blood pressures not adequately controlled (SBP >140 mmHg and/or DBP >85 mmHg in clinic and on daytime mean ambulatory blood pressure monitoring) despite treatment with the maximum tolerated dose of 3 antihypertensive agents.
- •Additional antihypertensive treatment deemed appropriate by the patients' doctor.
- •Patients' current antihypertensive treatment includes a thiazide diuretic and a least one of: a beta blocker, angiotensin converting enzyme inhibitor or angiotensin II receptor antagonist (i.e. modern antihypertensive regime where spironolactone is least likely to be effective).
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Definite indication or contraindication for spironolactone.
- •Known Conn's syndrome.
- •Heart failure NYHA class III or IV.
- •Known hepatic failure or significant cirrhosis.
- •Known pregnancy or women planning pregnancy.
- •Women of child-bearing potential not using adequate contraception methods.
- •Serum creatinine >221 µmol/l.
- •Serum potassium >5 mmol/l.
- •Clinic blood pressure or daytime ambulatory blood pressure >240/120 mmHg.
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