The Effect of Estrogen and Progesterone Levels on Knee and Ankle Joint Laxity

• Conditions: Healthy

• Registration Number: NCT00005923
• Lead Sponsor: National Center for Research Resources (NCRR)

Brief Summary

The proposed research is an observational study designed to compare estrogen and progesterone serum levels with knee and ankle joint laxity, and muscle reaction time as a measure of neuromuscular function. Three groups of women athletes with differing estrogen and progesterone profiles (normal menstrual cycles, amenorrheic, and exogenous estrogen supplementation) and one control group (male collegiate athletes) will be used to compare differences in joint laxity and neuromuscular function. Blood levels of estrogen and progesterone will be measured at four time points across the menstrual cycle. Joint laxity and muscle reaction time will also be measured at each of these points. The investigator hypothesizes that knee and ankle joint laxity and muscle reaction time will significantly increase with increasing estrogen and progesterone levels.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2000-06-23
• Study First Submitted QC: 2000-06-23
• Study First Posted: 2000-06-26
• Status Verified: 2001-11
• Last Update Submitted: 2005-06-23
• Last Update Posted: 2005-06-24

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• pre-collegiate or collegiate athletes

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

University of Vermont; 🇺🇸 Burlington, Vermont, United States