Correlation Between Serum Progesterone Level And Primary Dysmenorrhea

Completed

• Conditions: Primary Dysmenorrhea

• Registration Number: NCT06359457
• Lead Sponsor: Cairo University

Brief Summary

This study will be conducted to determine the correlation between the levels of serum progesterone and Menstrual Symptoms In Young Females with primary dysmenorrhea.

Detailed Description

One hundred adult females with primary dysmenorrhea will participate in this study. They will be recruited from the Gynaecological outpatient clinic, Kasr El Ainy University Hospital, Cairo, Egypt Many studies reported that primary dysmenorrhea was the result of increased prostaglandin, especially prostaglandin F2α (PGF2α) and prostaglandin E2 (PGE2) which produced the effect through the cyclooxygenase pathway, and further led to uterine ischemia hypoxia. Nevertheless the relationship between the serum progesterone level and menstrual symptoms was not completely clear. Hence, this study will investigate the association between the serum progesterone level and menstrual symptoms in young females with primaryf dysmenorrhea.

Study Timeline

• Study First Submitted: 2024-03-30
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-10
• Study First Posted: 2024-04-11
• Study Start: 2024-05-05
• Primary Completion: 2024-12-15
• Study Completion: 2024-12-31
• Last Update Submitted: 2025-01-27
• Last Update Posted: 2025-01-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

1. One hundreds adult females were suffered from primary dysmenorrhea.
2. Their age was ranged from 17 to 24 years.
3. Their body mass index was ranged from 20 to 25 kg/m2.

Exclusion Criteria

• Any participant will be excluded from the study if they have:

  1. Irregulars or infrequent menstrual cycles.
  2. Pacemaker, Myasthenia gravis, hyperthyroidism, active tuberculosis and psychosis.
  3. Pelvic pathology.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum progesterone level	1 month	Blood samples will be taken by physician for each girl, and will send to laboratory center to measure the progesterone level in the blood. The normal serum progesterone level at 21st day is 4-20 ng
Pain intensity	1 month	It will be measured by Visual analogue scale. It is 10 cm line with values ranging from 0 to 10. 0 indicates no pain nd 10 indicates the worst pain.
Physical and psychological menstrual symptoms	1 month	It will be measured by menstrual symptoms questionnaire. It is 25 items split into two categories which used to assess the physical and psychological symptoms associated with dysmenorrhea. The score on each item ranged from 1 (never) to 5 (always) with a higher composite score indicating more symptoms
Correlation between serum progesterone level and pain	1 month	The correlation between serum progesterone level and pain intensity measured by the VAS will be conducted
Correlation between serum progesterone level and menstrual symptoms	1 month	The correlation between serum progesterone level and menstrual symptoms measured by the menstrual symptom questionnaire will be conducted

Trial Locations

Locations (1)

Menna Allah Youssef Nasr El-Dien; 🇪🇬 Cairo, Egypt