Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- serotonin transporter occupancy
研究概览
简要总结
To modeling the pharmacokinetic-pharmacodynamic(PK-PD) simulation with the plasma concentration and the transporter occupancy from OCD patients treated with escitalopram.
To examine the effect of G2677T/A single nucleotide polymorphism(SNP) of ABCB1 gene to the PK-PD modeling in OCD patients treated with escitalopram.
详细描述
To measure plasma concentration of escitalopram in OCD patients treated with escitalopram.
To measure serotonin transporter occupancy by escitalopram in OCD patients treated with escitalopram.
To genotype G2677T/A SNP of ABCB1 gene in OCD patients treated with escitalopram.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of OCD based on Diagnostic and Statistical Manual(DSM)-IV criteria
- •no change of escitalopram dosage in 6 weeks
排除标准
- •psychiatric comorbidity other than OCD
- •History of head injury, epilepsy, other general medical disorder
结局指标
主要结局
serotonin transporter occupancy
时间窗: 72hr after oral administration of escitalopram
次要结局
- genotype(baseline)
- Yale-Brown Obsessive Compulsive Scale(Y-BOCS) Score(baseline)
- serotonin transporter occupancy(within the first 24hrs after oral administration of escitalopram)
- escitalopram plasma concentration(within 72 hours after oral administration of escitalopram)
研究者
Jun Soo Kwon
Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in OCD Patients
Seoul National University Hospital