Use of Determination of Drug Levels to Optimize Pharmacotherapy of Heart Failure
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Determination of the rate of significance between the serum concentration of the used medicinal products and the dose of this medicinal product
研究概览
简要总结
The aim of this study is to determine whether and how serum concentrations of the used medicinal products, including their metabolites, correlate with selected clinical indicators of heart failure (NT-proBNP concentration, 6-minute walk test, quality of life questionnaire, echocardiographic parameters, hospitalization for HFrEF, length of survival).
详细描述
The prevalence of chronic heart failure increases with age, and this disease is one of the most common reasons for hospitalization in the elderly. In order to reduce the number of exacerbations, the frequency of hospitalizations, morbidity and mortality and improve the overall quality of life, the treatment strategy should be individually set for each patient, regularly monitored and reviewed.
Patients with chronic heart failure show significant differences in the pharmacokinetics of both cardiovascular and non-cardiovascular drugs. At the same time, they tend to be exposed to other prescribed medicinal products, and therefore there is an increased risk of drugs interactions. These findings emphasize the need for comprehensive pharmacokinetic studies in patients with chronic heart failure, together with the exploration of the potential benefit of biomarkers suitable for monitoring the clinical status of patients. Pharmacotherapy of chronic heart failure with reduced ejection fraction (Heart Failure with Reduced Ejection Fraction - HFrEF) currently consists of beta-blockers together with mineralocorticoid receptor antagonists, the combination of sacubitril/valsartan drugs and sodium-glucose transporter 2 inhibitors. Although the recommendation of therapeutic drug monitoring (TDM) in patients with chronic heart failure has not yet been established, its introduction can serve as an effective tool for detecting changes in the pharmacokinetics of drugs used, objectifying drug interactions and ascertaining patient adherence to treatment, thereby becoming part of safe personalized pharmacotherapy of this disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HFrEF with already established or newly started treatment with the listed medicinal products
- •Male and female patients over 18 years of age
- •Signed Informed Consent with participation in the study
- •Women of childbearing potential must have a negative serum human chorionic gonadotropin (hCG) result at baseline and use an acceptable method of contraception with a home control urine pregnancy test every 3 months throughout the duration of the study
排除标准
- •Hypersensitivity to the medicinal substance or to any auxiliary substance
- •Pregnant and breastfeeding women
- •Additional exclusion criteria for patients taking Bisoprolol, Carvedilol, Metoprolol succinate or Nebivolol: Unstable or decompensated heart failure belonging to New York Heart Association (NYHA) group IV according to the New York Heart Association classification, requiring intravenous inotropic support
- •Additional exclusion criteria for patients using Bisoprolol, Carvedilol, Metoprolol succinate or Nebivolol:
- •- Clinically manifest liver dysfunction
- •- History of bronchospasm or asthma
- •- Severe obstructive airways disease
- •- 2nd and 3rd degree A-V block (unless a permanent pacemaker is implanted)
- •- severe bradycardia (heart rate <50)
- •- 2nd and 3rd degree A-V block (unless a permanent pacemaker is implanted)
- •- severe bradycardia (heart rate <50)
- •- cardiogenic shock
- •- sinus node dysfunction syndrome (including sinoatrial block)
- •- severe hypotension (systolic blood pressure <85 mmHg)
- •- Prinzmetal angina
- •- untreated pheochromocytoma
- •- metabolic acidosis
- •- severe peripheral arterial circulation disorders
- •- concurrent intravenous treatment with verapamil or diltiazem
- •Additional exclusion criteria for patients using Spironolactone:
- •- acute renal failure
- •- severe renal impairment (estimated glomerular filtration rate <10 ml/min)
- •- hyperkalemia >5.5 mmol/l
- •- hyponatremia <125 mmol/l
- •- Addison's disease
- •- concurrent use of eplerenone or other potassium-sparing diuretics
- •- porphyria
- •Additional exclusion criteria for patients using Sacubitril/Valsartan:
- •- concomitant use with Angiotensin converting enzyme (ACE) inhibitors
- •- angioedema related to previous ACE inhibitor treatment or a history of angiotensin II receptor blockers (ARB) treatment
- •- hereditary or idiopathic angioedema
- •- concomitant use with medicinal products containing Aliskiren in patients with diabetes mellitus or in patients with impaired renal function (eGFR <60 ml/min/1.73 m2)
- •- severe liver dysfunction, biliary cirrhosis and cholestasis
研究组 & 干预措施
Patients with Heart Failure with Reduced Ejection Fraction
Patients with heart failure with reduced ejection fraction, aged 18+, dispensary at the Cardiology Outpatient Clinic for Heart Failure University Hospital Ostrava, who are orally administered tablets one of the evaluated medicinal products or their combination as indicated by the attending physician (Nebivolol, Valsartan and Sacubitril, Carvedilol, Bisoprolol, Metoprolol, Spironolactone).
干预措施: Nebivolol (Drug)
Patients with Heart Failure with Reduced Ejection Fraction
Patients with heart failure with reduced ejection fraction, aged 18+, dispensary at the Cardiology Outpatient Clinic for Heart Failure University Hospital Ostrava, who are orally administered tablets one of the evaluated medicinal products or their combination as indicated by the attending physician (Nebivolol, Valsartan and Sacubitril, Carvedilol, Bisoprolol, Metoprolol, Spironolactone).
干预措施: Valsartan and Sacubitril (Drug)
Patients with Heart Failure with Reduced Ejection Fraction
Patients with heart failure with reduced ejection fraction, aged 18+, dispensary at the Cardiology Outpatient Clinic for Heart Failure University Hospital Ostrava, who are orally administered tablets one of the evaluated medicinal products or their combination as indicated by the attending physician (Nebivolol, Valsartan and Sacubitril, Carvedilol, Bisoprolol, Metoprolol, Spironolactone).
干预措施: Carvedilol (Drug)
Patients with Heart Failure with Reduced Ejection Fraction
Patients with heart failure with reduced ejection fraction, aged 18+, dispensary at the Cardiology Outpatient Clinic for Heart Failure University Hospital Ostrava, who are orally administered tablets one of the evaluated medicinal products or their combination as indicated by the attending physician (Nebivolol, Valsartan and Sacubitril, Carvedilol, Bisoprolol, Metoprolol, Spironolactone).
干预措施: Bisoprolol (Drug)
Patients with Heart Failure with Reduced Ejection Fraction
Patients with heart failure with reduced ejection fraction, aged 18+, dispensary at the Cardiology Outpatient Clinic for Heart Failure University Hospital Ostrava, who are orally administered tablets one of the evaluated medicinal products or their combination as indicated by the attending physician (Nebivolol, Valsartan and Sacubitril, Carvedilol, Bisoprolol, Metoprolol, Spironolactone).
干预措施: Metoprolol (Drug)
Patients with Heart Failure with Reduced Ejection Fraction
Patients with heart failure with reduced ejection fraction, aged 18+, dispensary at the Cardiology Outpatient Clinic for Heart Failure University Hospital Ostrava, who are orally administered tablets one of the evaluated medicinal products or their combination as indicated by the attending physician (Nebivolol, Valsartan and Sacubitril, Carvedilol, Bisoprolol, Metoprolol, Spironolactone).
干预措施: Spironolactone (Drug)
结局指标
主要结局
Determination of the rate of significance between the serum concentration of the used medicinal products and the dose of this medicinal product
时间窗: 24 month
Determination whether the serum concentration of used medicinal products (Nebivolol, Valsartan/Sacubitril, Carvedilol, Bisoprolol, Metoprolol, Spironolactone) is more important than the dose of these medicinal products for compensating health status in patients with chronic heart failure with reduced ejection fraction (HFrEF).
次要结局
- Clinical indicator - Minnesota Living With Heart Failure Questionnaire(24 month)
- Clinical indicator - NT-proBNP concentration(24 month)
- Clinical indicator - 6-minute walk test(24 month)
- Clinical indicator - Echocardiographic examination(24 month)
- Clinical indicator - The hospitalization for HFrEF(24 month)
- Clinical indicator - The length of survival(24 month)
- Non-adherence to treatment(24 month)
- Adverse effects(24 month)