Image guidance in neurosurgery: Flatpanel-Detector Parenchymal Blood Volume imaging and Magnetic Resonance - Dynamic Contrast Enhanced perfusion imaging in meningiomas

Recruiting

Conditions: meningeal tumor
Meningioma
10029211
10009720

Registration Number: NL-OMON49397

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 10

Inclusion Criteria

- Diagnosed with an intracranial meningioma, located above the tentorium in
convexity or falx.
- Scheduled for resection via craniotomy, including standard pre-operative MRI.
- Age >= 50 years

Exclusion Criteria

- History of intracranial surgery
- History of major stroke with residual morbidity, significantly altering
intracranial hemodynamics (e.g. large vessel occlusion)
- Impaired kidney function (eGFR < 45 ml/min/1.73m2)
- History of genetic disease increasing the risk of (radiation-induced)
cerebral malignancies:
Multiple Endocrine Neoplasia (MEN), Neurofibromatosis (NF), von Hippel-Lindau
disease (VHL)
- Allergy to iodine or gadolinium contrast agents
- MR-related contraindication: ferromagnetic implants, claustrophobia etc.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary objective of this study is to assess the feasibility of FD-PBV imaging<br /><br>in meningiomas; image quality of scans including reconstructed colour coded<br /><br>maps and vascular images will be evaluated by neurosurgeons and an experienced<br /><br>neuroradiologist using a standardized scoring form. Besides a descriptive<br /><br>analysis of this new application, yielded images and hemodynamic parameters<br /><br>will be compared with MR-DCE perfusion imaging and current literature.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints of this study include:<br /><br>- Added value in neurosurgery, assessed by a neuroradiologist and operating<br /><br>neurosurgeon,<br /><br>- Practical workflow, extra time spent under general anaesthesia, effective<br /><br>contrast/radiation dose and learning curve,<br /><br>- (Intraclass) correlation coefficients calculated of the obtained hemodynamic<br /><br>parameters between imaging techniques.</p><br>