Comparison between two methods of intravenous titration of morphine for rapid control of severe cancer pain: patient-controlled analgesia using optimizing B.I. mode vs. conventional method

Not Applicable

Completed

• Conditions: Neoplasms

• Registration Number: KCT0004008
• Lead Sponsor: Yonsei University Health System, Severance Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-05-26
• Last Update Posted: 6 March 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

1. Cancer patient, age of 19 or more
2. Life expectancy more than a month
3. Admitted patient
4. Failure of appropriate pain control by oral or transdermal opioids
5. Average daily pain score (numerical rating scale; NRS) 4 or more of previous 3 days
6. Painkiller equivalent to intravenous morphine of 10-200mg/day for previous 24 hours
7. Voluntarily participated patients with informed consent

Exclusion Criteria

1. Contraindication for studied drug(morphine sulfate) intravenous infusion (had hypersensitivity, persistent asthma attack, severe respiratory distress to opioid drug)
2. Patients with uncontrolled psychiatric disease
3. Patients who can't read the informed consent form(Illiterates, foreigners)
4. Patients with cognitive impairment evaluated by Korean Mini-Mental State Examination(K-MMSE)

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference of average times of patient having breakthrough pain(NRS of more 4 or more) between two groups

Secondary Outcome Measures

Name	Time	Method
Analgesic effect;Psychological effect;safety