Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy
Phase 4
Completed
- Conditions
- Contrast-Induced Nephropathy
- Interventions
- Drug: Isotonic Saline
- Registration Number
- NCT00606827
- Lead Sponsor
- Ospedale Misericordia e Dolce
- Brief Summary
Contrast-induced nephrophaty (CIN) accounts for more than 10% of hospital-acquired renal failure. Hydration with sodium bicarbonate is more protective than isotonic saline in animals. Limited data are available in humans. We compared the efficacy of sodium bicarbonate versus isotonic saline to prevent CIN in a large population of patients with renal dysfunction undergoing coronary angiography or intervention.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 500
Inclusion Criteria
- patients with creatinine clearance < 60 mL/min
Exclusion Criteria
- contrast medium administration within the previous 10 days
- end-stage renal failure requiring dialysis
- refusal to give informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description B Isotonic Saline Saline A Sodium Bicarbonate Bicarbonate
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie sodium bicarbonate's protective effect against contrast-induced nephropathy in coronary angiography patients?
How does sodium bicarbonate hydration compare to isotonic saline in preventing CIN in high-risk renal dysfunction populations?
Which biomarkers correlate with contrast-induced nephropathy risk and response to sodium bicarbonate treatment in clinical studies?
What are the adverse event profiles of sodium bicarbonate versus saline hydration in patients undergoing coronary interventions?
Are there combination therapies or alternative agents that enhance sodium bicarbonate's efficacy in preventing CIN compared to monotherapy?
Trial Locations
- Locations (1)
Ospedale Misericordia e Dolce
🇮🇹Prato, Italy
Ospedale Misericordia e Dolce🇮🇹Prato, Italy