Sodium bicarbonate

Generic Name: Sodium bicarbonate

Brand Names: Alka-seltzer, Alka-seltzer Fruit Chews, Alka-seltzer Heartburn Relief, Bi-peglyte, Bibag, Bicart, Bss Ophthalmic Solution, Ceo-two, Colyte, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hema Bp-38, Hemacart, Konvomep, Nulytely, Peglyte, Phoxillum, Physioneal 40, Prismasol, Zegerid, Zegerid Reformulated Aug 2006, Zegerid With Magnesium Hydroxide

Drug Type: Small Molecule

Chemical Formula: CHNaO_₃

CAS Number: 144-55-8

Unique Ingredient Identifier: 8MDF5V39QO

Background: Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Indication: Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.

Associated Conditions: Barbiturate intoxication, Breast Cancer, Constipation, Dental Decay, Duodenal Ulcer, Dyspepsia, Gastro-esophageal Reflux Disease (GERD), Gingival Bleeding, Heartburn, Helicobacter Infections, Hyperkalemia, Ischaemia, Metabolic Acidosis, Myocardial Infarction, Plaque, Dental, Pruritis of the skin, Skin Irritation, Upper GI Bleeding, Upset stomach, Zollinger-Ellison Syndrome, Abdominal bloating, Benign, active Gastric Ulcer, Methyl alcohol poisoning, Prophylaxis of Contrast-induced nephropathy, Salicylate poisoning, Severe Diarrhea, Swelling of the gums

Associated Therapies: Bowel preparation therapy

Clinical Trials

Use of Sodium Bicarbonate As Prophylaxis for Kidney Damage in Patients with Heatstroke

Not Applicable

Recruiting

Conditions: Heat Stroke
Acute Kidney Injury
Acute Kidney Injury Due to Hypovolaemia

Interventions: Drug: Sodium bicarbonate
Other: No intervention

First Posted Date: 2024-10-02

Last Posted Date: 2024-10-02

Lead Sponsor: Hospital General de Mexicali

Target Recruit Count: 1

Registration Number: NCT06622525

Locations: 🇲🇽
Hospital General de Mexicali, Mexicali, Baja California, Mexico

Impact of Sodium Bicarbonate on 24-hour Urine Parameters in Hypocitriuric and Uric Acid Stone Formers

Phase 1

Not yet recruiting

Conditions: Uric Acid Stones

Interventions: Drug: Potassium citrate
Drug: Sodium bicarbonate

First Posted Date: 2024-03-28

Last Posted Date: 2025-01-27

Lead Sponsor: University of California, Irvine

Target Recruit Count: 100

Registration Number: NCT06335537

Locations: 🇺🇸
University of California, Irvine Medical Center, Orange, California, United States

A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants

Phase 1

Completed

Conditions: Healthy
Obese
Overweight

Interventions: Drug: Orforglipron
Drug: Simvastatin
Drug: Digoxin
Drug: Rosuvastatin
Drug: Acetaminophen
Drug: Midazolam
Drug: Sodium Bicarbonate

First Posted Date: 2024-01-02

Last Posted Date: 2024-07-22

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 50

Registration Number: NCT06186622

Locations: 🇺🇸
Fortrea Clinical Research Unit Inc., Dallas, Texas, United States

Dietary Acid Reduction and Progression of Chronic Kidney Disease

Not Applicable

Completed

Conditions: Cardiovascular Diseases
Hypertension
Chronic Kidney Diseases

Interventions: Other: Fruits and vegetables (F+V)
Other: Usual Care
Drug: NaHCO3 Tablets

First Posted Date: 2023-09-21

Last Posted Date: 2023-09-21

Lead Sponsor: University of Texas at Austin

Target Recruit Count: 153

Registration Number: NCT06046924

Combination of Buffered Anesthetic to Treat Mandibular Molars

Phase 4

Terminated

Conditions: Symptomatic Irreversible Pulpitis

Interventions: Drug: Sodium bicarbonate
Drug: Articaine w/ epi
Drug: Lidocaine w/ epi
Drug: Mepivacaine plain

First Posted Date: 2023-09-21

Last Posted Date: 2025-05-13

Lead Sponsor: Indiana University

Target Recruit Count: 40

Registration Number: NCT06047366

Locations: 🇺🇸
ndiana University School of Dentistry Graduate Endodontics Dept., Indianapolis, Indiana, United States

Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease: Sympatholysis in CKD

Phase 2

Recruiting

Conditions: Chronic Kidney Disease

Interventions: Drug: Sodium Bicarbonate
Behavioral: Exercise Training
Drug: Placebo

First Posted Date: 2023-07-03

Last Posted Date: 2023-07-03

Lead Sponsor: Emory University

Target Recruit Count: 156

Registration Number: NCT05928936

Locations: 🇺🇸
Emory Clinic, Atlanta, Georgia, United States
🇺🇸
Atlanta VA Medical Center, Decatur, Georgia, United States

Is Hyaluronic Acid Gel Effective on Oral Mucositis in Children Who Receiving Chemotherapy

Phase 4

Completed

Conditions: Oral Mucositis

Interventions: Drug: Sodium bicarbonate
Drug: Hyaluronic acid

First Posted Date: 2023-04-18

Last Posted Date: 2023-04-18

Lead Sponsor: Yuzuncu Yıl University

Target Recruit Count: 40

Registration Number: NCT05818007

Locations: 🇹🇷
Yuzuncu Yil University, Van, Turkey

SAINT: Safe Induction of Labor Trial

Phase 3

Recruiting

Conditions: Labor Complication
Induced; Birth
Pregnancy Related

Interventions: Drug: Buscopan 20 MG/ML Injectable Solution
Drug: Placebo
Drug: Nacl 0.9%
Drug: Sodium bicarbonate

First Posted Date: 2023-02-09

Last Posted Date: 2024-04-04

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 3000

Registration Number: NCT05719467

Locations: 🇳🇴
Akershus University Hospital, Lørenskog, Norway
🇳🇴
Oslo University Hospital Ullevål, Oslo, Norway
🇳🇴
The University Hospital of North Norway, Tromsø, Norway

and more 2 locations

SODium BICarbonate for Metabolic Acidosis in the ICU

Phase 3

Recruiting

Conditions: Metabolic Acidosis
Shock

Interventions: Drug: 5% Dextrose
Drug: Sodium bicarbonate

First Posted Date: 2023-01-26

Last Posted Date: 2024-06-21

Lead Sponsor: Australian and New Zealand Intensive Care Research Centre

Target Recruit Count: 500

Registration Number: NCT05697770

Locations: 🇳🇿
Auckland City Hospital, Auckland, New Zealand
🇦🇺
Canberra Hospital, Garran, Australian Capital Territory, Australia
🇦🇺
Mater Hospital, South Brisbane, Queensland, Australia

and more 24 locations

Sodium Bicarbonate for Acute Peripheral Vertigo

Not Applicable

Recruiting

Conditions: Peripheral Vertigo

Interventions: Drug: Diphenhydramine + Sodium Bicarbonate
Drug: Diphenhydramine
Drug: Sodium Bicarbonate

First Posted Date: 2023-01-09

Last Posted Date: 2023-07-12

Lead Sponsor: National Taiwan University Hospital

Target Recruit Count: 225

Registration Number: NCT05676216

Locations: 🇨🇳
National Taiwan University Yunlin Branch, Yunlin County, Taiwan

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