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Sodium bicarbonate

Generic Name
Sodium bicarbonate
Brand Names
Alka-seltzer, Alka-seltzer Fruit Chews, Alka-seltzer Heartburn Relief, Bi-peglyte, Bibag, Bicart, Bss Ophthalmic Solution, Ceo-two, Colyte, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hema Bp-38, Hemacart, Konvomep, Nulytely, Peglyte, Phoxillum, Physioneal 40, Prismasol, Zegerid, Zegerid Reformulated Aug 2006, Zegerid With Magnesium Hydroxide
Drug Type
Small Molecule
Chemical Formula
CHNaO3
CAS Number
144-55-8
Unique Ingredient Identifier
8MDF5V39QO

Overview

Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Background

Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.

Indication

Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.

Associated Conditions

  • Barbiturate intoxication
  • Breast Cancer
  • Constipation
  • Dental Decay
  • Duodenal Ulcer
  • Dyspepsia
  • Gastro-esophageal Reflux Disease (GERD)
  • Gingival Bleeding
  • Heartburn
  • Helicobacter Infections
  • Hyperkalemia
  • Ischaemia
  • Metabolic Acidosis
  • Myocardial Infarction
  • Plaque, Dental
  • Pruritis of the skin
  • Skin Irritation
  • Upper GI Bleeding
  • Upset stomach
  • Zollinger-Ellison Syndrome
  • Abdominal bloating
  • Benign, active Gastric Ulcer
  • Methyl alcohol poisoning
  • Prophylaxis of Contrast-induced nephropathy
  • Salicylate poisoning
  • Severe Diarrhea
  • Swelling of the gums

Clinical Trials

FDA Approved Products

Elliotts B
Manufacturer:Lukare Medical, LLC
Route:INTRATHECAL
Strength:19 mg in 10 mL
Approved: 2018/11/16
NDC:55792-007
Omeprazole and Sodium Bicarbonate
Manufacturer:Oceanside Pharmaceuticals
Route:ORAL
Strength:1680 mg in 1 1
Approved: 2023/10/11
NDC:68682-991
Omeprazole and Sodium Bicarbonate
Manufacturer:Ajanta Pharma USA Inc.
Route:ORAL
Strength:1100 mg in 1 1
Approved: 2023/11/23
NDC:27241-032
omeprazole and sodium bicarbonate
Manufacturer:Zydus Pharmaceuticals USA Inc.
Route:ORAL
Strength:1100 mg in 1 1
Approved: 2023/03/24
NDC:68382-501
PEG-3350 and Electrolytes
Manufacturer:A-S Medication Solutions
Route:ORAL
Strength:6.74 g in 4 L
Approved: 2022/09/28
NDC:50090-6521

Singapore Approved Products

BIBAG (5008 DESIGN) POWDER FOR HAEMODIALYSIS
Manufacturer:Fresenius Medical Care SMAD
Form:POWDER, FOR SOLUTION
Strength:100 %
Online:Yes
Approved: 2010/07/02
Approval:SIN13822P
Ural Effervescent Granules
Manufacturer:Aspen Pharma Pty Ltd
Form:GRANULE, EFFERVESCENT
Strength:1.76g
Online:Yes
Approved: 2013/06/26
Approval:SIN14374P
BIBAG POWDER FOR HAEMODIALYSIS
Manufacturer:Fresenius Medical Care - SMAD
Form:POWDER, FOR SOLUTION
Strength:100%
Online:Yes
Approved: 1998/12/22
Approval:SIN10583P
GASCOVID LIQUID
Manufacturer:Hovid Berhad
Form:SUSPENSION
Strength:267 mg/10ml
Online:Yes
Approved: 2020/11/17
Approval:SIN16041P
OHTA'S ISAN ANTACID POWDER
Manufacturer:OHTA'S ISAN CO LTD
Form:POWDER
Strength:600 mg/1.3 g
Online:Yes
Approved: 1991/05/03
Approval:SIN05820P

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