Use of Sodium Bicarbonate As Prophylaxis for Kidney Damage in Patients with Heatstroke
Overview
- Phase
- N/A
- Intervention
- Sodium bicarbonate
- Conditions
- Heat Stroke
- Sponsor
- Hospital General de Mexicali
- Enrollment
- 1
- Locations
- 1
- Primary Endpoint
- The use of sodium bicarbonate reduces the need for renal replacement therapy
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This study protocol aims to prevent the need for renal replacement therapy in patients with rhabdomyolysis secondary to heatstroke. It is based on previous studies showing that bicarbonate infusion reduces renal failure in similar contexts. The intervention will be conducted at the General Hospital of Mexicali during the summer, targeting the prevention of renal failure and reducing the necessity for renal replacement therapy.
Detailed Description
The present study protocol explores the possibility of preventing the need for renal replacement therapy in patients who develop rhabdomyolysis secondary to heatstroke. This is based on previous studies that have used bicarbonate infusion in the context of rhabdomyolysis secondary to compartment syndrome, finding a lower incidence of renal failure. Due to the aforementioned, we propose to carry out a similar intervention at the General Hospital of Mexicali, where there is a significant incidence of heatstroke during the summer months. The aim is to determine whether this intervention is useful in preventing the development of renal failure and the requirement for renal replacement therapy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Admitted to the General Hospital of Mexicali with the diagnosis of heat stroke.
- •Meeting the operational definition (exposure to heat, body temperature at admission greater than 40 degrees Celsius).
- •CPK level greater than 1000 U/L.
- •Having informed consent from the patient or the legally responsible adult.
Exclusion Criteria
- •Exclusion of the heat stroke diagnosis during their evaluation.
- •Lack of serum creatinine levels at the time of admission to the protocol.
Arms & Interventions
Intervention Group
This group will receive 100 mEq of sodium bicarbonate diluted in one liter of saline solution, administered at a rate of 100 ml/h, with the goal of maintaining a urinary pH greater than 6.5.
Intervention: Sodium bicarbonate
Control Group
This group will be manage with the usual care that is given to patients with heat stroke in this hospital.
Intervention: No intervention
Outcomes
Primary Outcomes
The use of sodium bicarbonate reduces the need for renal replacement therapy
Time Frame: From enrollment until discharge or death.
Determine if the use of sodium bicarbonate as a prophylactic measure reduces the need for renal replacement therapy in patients with heat stroke-associated rhabdomyolysis.
Secondary Outcomes
- Potassium levels in patients diagnosed with heat stroke who received bicarbonate compared to those who did not receive bicarbonate.(From enrollment until discharge or death.)
- Creatinine levels(From enrollment until discharge or death.)
- Mortality rate(From enrollment until discharge or death.)
- Mortality rate of patients diagnosed with heat stroke who were administered bicarbonate compared to those who did not receive bicarbonate.(From enrollment until discharge or death.)
- Difference in the length of hospital stay for patients diagnosed with heat stroke who received bicarbonate compared to those who did not receive bicarbonate.(From enrollment until discharge or death.)
- Difference in the requirements for vasopressors in patients diagnosed with heat stroke who received bicarbonate compared to those who did not receive bicarbonate.(From enrollment until discharge or death.)
- Use of mechanical ventilation in patients diagnosed with heat stroke(From enrollment until discharge or death.)