Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate Bolus Injection in Patients Undergoing an Emergent Coronary Procedure
Overview
- Phase
- Phase 4
- Intervention
- Sodium bicarbonate
- Conditions
- Emergent Coronary Procedure
- Sponsor
- Osaka General Medical Center
- Enrollment
- 59
- Locations
- 1
- Primary Endpoint
- Occurrence of Contrast-induced Nephropathy
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
This study is to investigate the effect of Sodium Bicarbonate bolus injection in patients undergoing an emergent coronary procedure for prevention of contrast-induced nephropathy.
Detailed Description
This study is to investigate the effect of Sodium Bicarbonate bolus injection in patients undergoing an emergent coronary procedure for prevention of contrast-induced nephropathy.The End point is development of contrast-induced nephropathy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing an emergent coronary procedure(within 60 minutes from admission)
Exclusion Criteria
- •On dialysis
- •Pregnancy
- •Past use of bicarbonate or N-Acetyl-Cystein in 48hr
- •Past exposure to contrast media in 48hr
- •Circulatory insufficiency with lactic acidosis.
Arms & Interventions
Sodium bicarbonate
Intervention: Sodium bicarbonate
Sodium chloride
Intervention: Sodium Chloride
Outcomes
Primary Outcomes
Occurrence of Contrast-induced Nephropathy
Time Frame: after procedure and 1,2-3day after procedure
The primary endpoint was the occurrence of contrast-induced nephropathy, defined as an increase \>0.5 mg/dl or \>25% in serum Cr concentration within 2 days of the procedure compared to the baseline level.