Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate Bolus Injection
- Conditions
- Emergent Coronary Procedure
- Interventions
- Registration Number
- NCT00700375
- Lead Sponsor
- Osaka General Medical Center
- Brief Summary
This study is to investigate the effect of Sodium Bicarbonate bolus injection in patients undergoing an emergent coronary procedure for prevention of contrast-induced nephropathy.
- Detailed Description
This study is to investigate the effect of Sodium Bicarbonate bolus injection in patients undergoing an emergent coronary procedure for prevention of contrast-induced nephropathy.The End point is development of contrast-induced nephropathy.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 59
- Patients undergoing an emergent coronary procedure(within 60 minutes from admission)
- On dialysis
- Pregnancy
- Past use of bicarbonate or N-Acetyl-Cystein in 48hr
- Past exposure to contrast media in 48hr
- Circulatory insufficiency with lactic acidosis.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sodium bicarbonate Sodium bicarbonate - Sodium chloride Sodium Chloride -
- Primary Outcome Measures
Name Time Method Occurrence of Contrast-induced Nephropathy after procedure and 1,2-3day after procedure The primary endpoint was the occurrence of contrast-induced nephropathy, defined as an increase \>0.5 mg/dl or \>25% in serum Cr concentration within 2 days of the procedure compared to the baseline level.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (1)
Osaka General Medical Center
🇯🇵Osaka, Japan
Osaka General Medical Center🇯🇵Osaka, Japan