Prevention of Contrast-induced Nephropathy in Patients With Acute Myocardial Infarction
Overview
- Phase
- N/A
- Intervention
- Hydration
- Conditions
- Contrast Induced Nephropathy
- Sponsor
- Odense University Hospital
- Enrollment
- 720
- Locations
- 1
- Primary Endpoint
- Prevention of contrast induced nephropathy in STEMI patients treated with primary PCI
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
OBJECTIVE: To evaluate the efficacy of prevention of contrast induced nephropathy in patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention.
DESIGN: Prospective study. SETTING: Three-center study Acute kidney injury was defined as a rise in creatinine >25% from baseline Serum creatinine will be measured at baseline and each day for the following 3 days and at 30 days.
Patients will be randomised to:
- Standard treatment
- Standard treatment + acetylcystein for 2 days
- Standard treatment + Sodium bicarbonate 500 ml / followed by 100 ml/h for 5 hours
- Standard treatment + acetylcystein for 2 days + Sodium bicarbonate 500 ml / followed by 100 ml/h for 5 hours
Investigators
Lisette Okkels Jensen
MD DMSci PhD
Odense University Hospital
Eligibility Criteria
Inclusion Criteria
- •STEMI patients treated with primary PCI
Exclusion Criteria
- •Cardiogenic shock
Arms & Interventions
Standard treatment
Hydration
Intervention: Hydration
Combined Acetylcystein and Sodium Bicarbonat
Intervention: Combined Acetylcystein and Sodium Bicarbonate
Sodium Bicarbonate
Intervention: Sodium bicarbonate
Acetylcystein for 2 days
Standard treatment + acetylcystein for 2 days
Intervention: Acetylcysteine
Outcomes
Primary Outcomes
Prevention of contrast induced nephropathy in STEMI patients treated with primary PCI
Time Frame: from baseline to day 3
Rise in creatinine \>25% from baseline to day 3
Secondary Outcomes
- Prevention of contrast induced nephropathy in STEMI patients treated with primary PCI(from baseline to day 30)