The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
Overview
- Phase
- Phase 4
- Intervention
- sodium bicarbonate
- Conditions
- Acute Kidney Injury
- Sponsor
- Yonsei University
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Comparison of the the peak creatinine level during the postoperative 48h by more than 0.3 mg/dL between two groups.
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The purpose of study is to test whether perioperative sodium bicarbonate infusion can prevent acute kidney injury following open heart surgery in infective endocarditis patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •adult patients over the age of 20 scheduled for open heart surgery for infective endocarditis
Exclusion Criteria
- •end stage renal disease (serum creatinine concentration \> 300 μmol/L)
- •on dialysis
- •chronic moderate to high dose corticosteroid therapy (\> 10 mg/day prednisolon or equivalent)
- •preoperative severe hypernatremia (Na+ \> 150 mmol/L), alkalemia (PH \> 7.50), or pulmonary edema
- •neurocognitive dysfunction
Arms & Interventions
Sodium bicarbonate group
Sodium bicarbonate group
Intervention: sodium bicarbonate
Saline group
Saline group
Intervention: Saline
Outcomes
Primary Outcomes
Comparison of the the peak creatinine level during the postoperative 48h by more than 0.3 mg/dL between two groups.
Time Frame: postoperative 48 hours
We would investigate if the peak creatinine level during the postoperative 48h would differ by more than 0.3 mg/dL between two groups. The primary outcome was decided based on the AKIN criteria which defines acute kidney injury if serum creatinine increases more than 0.3 mg/dL during the postoperative 48 h. ; increase in serum creatinine of 0.3 mg/dL or \>50 percent developing over \<48 hours