Sodium Bicarbonate Supplementation in Athletes

Phase 3

Completed

• Conditions: Supplementation; Sport

• Registration Number: NCT03165357
• Lead Sponsor: Poznan University of Life Sciences

Brief Summary

The purpose of this study was to verify the effect of 10-day sodium bicarbonate (NaHCO3) and placebo (PLA) supplementation on body composition, physical capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Detailed Description

Sodium bicarbonate (NaHCO3) was proposed as an ergogenic agent, because it improves high-intensity and resistance exercise performance. Until now the major limitation to NaHCO3 supplementation has been the gastrointestinal (GI) side effects. Therefore, this study aims to examine the effect of chronic, progressive- dose NaHCO3 ingestion on physical capacity, body composition and concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Study Timeline

• Study Start: 2015-10-10
• Primary Completion: 2016-03-10
• Study Completion: 2016-04-05
• Status Verified: 2017-05
• Study First Submitted: 2017-05-22
• Study First Submitted QC: 2017-05-23
• Last Update Submitted: 2017-05-23
• Study First Posted: 2017-05-24
• Last Update Posted: 2017-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• written consent to participate,
• a current medical clearance to practice sports,
• training experience: at least 2 years (of CrossFit training),
• minimum of 3 workout sessions (CrossFit) a week,
• 20-43 years.

Exclusion Criteria

• current injury,
• any health-related contraindication,
• declared general feeling of being unwell,
• unwilling to follow the study protocol.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Changes in aerobic capacity after sodium bicarbonate supplementation	Baseline and after 10 days	The incremental cycling test (ICT)
Changes in specific performance capacity after sodium bicarbonate supplementation	Baseline and after 10 days	The CrossFit-specific physical fitness test: Fight Gone Bad (FGB)

Secondary Outcome Measures

Name	Time	Method
Changes of lactate and pyruvate concentration in blood after sodium bicarbonate supplementation	Baseline and after 10 days	Lactate \[mmol/L\] and pyruvate \[mmol/L\] concentration analysis
Changes in fat mass and fat free mass after sodium bicarbonate supplementation	Baseline and after 10 days	Fat mass (kg) and fat free mass (kg) analysis
Changes of red and white blood cell concentration in blood after sodium bicarbonate supplementation	Baseline and after 10 days	Red blood cells (RBC) \[mln/mm³\] and white blood cells (WBC) \[mln/mm³\] concentration analysis
Changes in blood glucose and hemoglobin concentration after sodium bicarbonate supplementation	Baseline and after 10 days	Hemoglobin (Hb) \[g/dl\] and glucose \[g/dl\] concentration analysis
Changes in blood hematocrit levels after sodium bicarbonate supplementation	Baseline and after 10 days	Hematocrit (HCT) \[%\] level analysis
Changes of creatine kinase and lactate dehydrogenase activity in blood after sodium bicarbonate supplementation	Baseline and after 10 days	Creatine kinase \[U/L\] and lactate dehydrogenase \[U/L\] activity analysis

Trial Locations

Locations (1)

Poznan University of Life Sciences, ul.Wojska Polskiego 31; 🇵🇱 Poznań, Wielkopolska, Poland