Impact of Subthalamic Nucleus Deep Brain Stimulation on Pain in Parkinson Disease : Clinical and Neurophysiological Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Modification of habituation in percentage, between tests performed before and after DBS
研究概览
简要总结
Pain is a common symptom of Parkinson's disease (PD) but the physiology remains poorly understood. Recent work suggests that subthalamic nucleus deep brain stimulation (STN-DBS) could make a profit on the pain in PD.
The investigator would drive a study with a follow up of PD patients before and after STN-DBS. The pain will be clinically explored by targeted questionnaires and electrophysiological through laser evoked potentials.
The questionnaires are designed to quantify and characterize the pain in these patients. Laser evoked potentials will, through repetitive stimulation, study both the functional status of the afferent nociceptive pathways, their habituation to repetitive nociceptive stimuli, and so better understand any abnormalities of the central processing of nociceptive information.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •A patient with idiopathic Parkinson's disease
- •Age between 30 and 70 inclusive.
- •No cognitive decline (MMS greater than or equal to 24)
- •Normal brain MRI
- •Informed consent signed
- •With or without pain sensation
排除标准
- •Presence of other neurological pathology that could explain the pain.
- •MMS less than 24
- •Pregnant or breastfeeding women
结局指标
主要结局
Modification of habituation in percentage, between tests performed before and after DBS
时间窗: After the second laser evoked potential which occurred around 3 months after STN-DBS
The habituation is the change of amplitude between the first and the second response of the double stimulation during the laser evoked potential. We calculated a percentage
次要结局
- Change in latency of laser evoked potential responses before and after DBS(After the second laser evoked potential which occurred around 3 months after STN-DBS)
- Change in amplitude of laser evoked potential responses before and after DBS(After the second laser evoked potential which occurred around 3 months after STN-DBS)