The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis

Not Applicable

• Conditions: Rheumatoid Arthritis
• Interventions: Other: Aerobic exercise

• Registration Number: NCT04439682
• Lead Sponsor: Gazi University

Brief Summary

Background: RA may progress with articular and non-articular involvement.Depression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain, decreased quality of life, fatigue and physical disability.BDNF level was found significantly lower in RA patients with depression. Aim of this study is to investigate the variation of BDNF, VEGF, TNF- α, IL-6, IL-1β, irisin and α- Klotho levels following acute exercise.

Methods: This study included 45 RA patients and 45 age and sex matched healthy controls. Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-06
• Study First Submitted: 2020-06-17
• Study First Submitted QC: 2020-06-17
• Last Update Submitted: 2020-06-17
• Study First Posted: 2020-06-19
• Last Update Posted: 2020-06-19
• Study Start: 2020-07-17
• Primary Completion: 2020-09-17
• Study Completion: 2021-06-17

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Patients who were aged between 18-65 years,
• Patients who got diagnosed according to American College of Rheumatology criteria
• Patients who were being followed at Firat University Department of Rheumatology

Exclusion Criteria

• Patients who had regular exercise habits, malignancy, pregnancy, incorporation,
• Patients who took anti-TNF treatment
• Patients who had changes of medical treatment in last 3 months
• Patients who diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity
• Patients who had cardiac symptoms according to New York Heart Association
• Patients who had dysfunction that can prevent physical activity

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Aerobic exercise	Aerobic exercise will be performed to healthy population for a single session
Study group	Aerobic exercise	Aerobic exercise will be performed for a single session

Primary Outcome Measures

Name	Time	Method
Irisin	1 minute	Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University.

Secondary Outcome Measures

Name	Time	Method
BDNF, VEGF, TNF- α, IL-6, IL-1β and α- Klotho	1 minute	Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University.

Trial Locations

Locations (1)

Songul Baglan Yentur; 🇹🇷 Elazığ, Turkey