The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Rheumatoid Arthritis
- Sponsor
- Gazi University
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Irisin
- Last Updated
- 5 years ago
Overview
Brief Summary
Background: RA may progress with articular and non-articular involvement.Depression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain, decreased quality of life, fatigue and physical disability.BDNF level was found significantly lower in RA patients with depression. Aim of this study is to investigate the variation of BDNF, VEGF, TNF- α, IL-6, IL-1β, irisin and α- Klotho levels following acute exercise.
Methods: This study included 45 RA patients and 45 age and sex matched healthy controls. Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention.
Investigators
Songul Baglan Yentur
Research Assistant
Firat University
Eligibility Criteria
Inclusion Criteria
- •Patients who were aged between 18-65 years,
- •Patients who got diagnosed according to American College of Rheumatology criteria
- •Patients who were being followed at Firat University Department of Rheumatology
Exclusion Criteria
- •Patients who had regular exercise habits, malignancy, pregnancy, incorporation,
- •Patients who took anti-TNF treatment
- •Patients who had changes of medical treatment in last 3 months
- •Patients who diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity
- •Patients who had cardiac symptoms according to New York Heart Association
- •Patients who had dysfunction that can prevent physical activity
Outcomes
Primary Outcomes
Irisin
Time Frame: 1 minute
Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University.
Secondary Outcomes
- BDNF, VEGF, TNF- α, IL-6, IL-1β and α- Klotho(1 minute)