Effect of Exercise on the Disease Activity of Rheumatoid Arthritis
Not Applicable
Completed
- Conditions
- Rheumatoid Arthritis
- Registration Number
- NCT00792675
- Lead Sponsor
- University of Nebraska
- Brief Summary
This study will evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weightlifting.
- Detailed Description
The goal of this study was to evaluate the effect of exercise on the number of swollen and tender joints associated with rheumatoid arthritis. It was hypothesized that persons would have less inflammation associated with rheumatoid arthritis after a 12 week exercise program of treadmill walking and weighlifting. Immune parameters were measured to determine potential mechanisms responsible for changes in inflammation with exercise.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 55
Inclusion Criteria
- a diagnosis of RA according to the ACR 1989 Criteria at least 6 months prior to enrollment in the study, but not longer than 12 years
- age 19 to 65 years old
- stable regimen of medication for 2 months with less than 10 mg/day of oral corticosteroids
- currently exercise < 2x/week for less than 30 minutes at less than 60% of his/her age predicted maximum heart rate
- Subjects must pass the Physical Activity Readiness Scale Questionnaire (PAR-Q)
Exclusion Criteria
- other serious health problems
- intra-articular injection within 6 weeks
- total joint replacement of the large joints
- use of beta-blockers
- inability to complete the submaximal exercise test
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Tender Joint Count 12 Weeks Swollen Joint Count 12 Weeks
- Secondary Outcome Measures
Name Time Method Pain (visual Analog Scale) 12 Weeks 50 Foot Walk Test 12 Weeks Patient Global Assessment 12 Weeks Modified-Health Assessment Questionnaire 12 Weeks SF-36 12 Weeks Practitioner Global Assessment 12 Weeks Timed-Stands Test 12 Weeks Estimated Aerobic Capacity (VO2max) 12 weeks
Trial Locations
- Locations (1)
Physical Activity Lab, University of Nebraska Omaha
🇺🇸Omaha, Nebraska, United States
Physical Activity Lab, University of Nebraska Omaha🇺🇸Omaha, Nebraska, United States