The Effects of Exercise on Progression of Disease and Quality of Life in Patients With Retinitis Pigmentosa - a Small Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4
- 试验地点
- 2
- 主要终点
- Change in Brain-Derived Neurotrophic Factor (BDNF) level before and after exercise
研究概览
简要总结
The purpose of this study is to look in humans at the relationship between moderate or little exercise and their potential effects on the retina in patients with Retinitis Pigmentosa (RP).
详细描述
Human studies have shown that regular exercise may have positive effects on common degenerative diseases such as Alzheimer's disease. Exercise has also shown to improve conditions the eye such as macular degenerations, glaucoma, and cataracts. Mice with retinal degeneration which were exposed to exercise showed that it helped to slow the rate of degeneration. The purpose of this study is to look in humans at the relationship between moderate or little exercise and their potential effects on the retina in patients with Retinitis Pigmentosa (RP).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Visual field no less than 10 degrees;
- •VA no worse than 20/200 in the better seeing eye.
排除标准
- •Not able to tolerate exercise due to an underlying medical condition.
研究组 & 干预措施
Moderate exercise
Subjects in the moderate exercise group will participate in Spin exercise designed by Dr. Nocera.
干预措施: Spin exercise (Other)
Mild exercise
Sessions will be focused on balance and stretching.
结局指标
主要结局
Change in Brain-Derived Neurotrophic Factor (BDNF) level before and after exercise
时间窗: Baseline, 3 and 6 months follow up.
Sertum levels of BDNF in patients before and exercise program will be measured by testing blood
次要结局
- Change in retina vasculature before and after exercise(Baseline, 3 and 6 months follow up.)
- Change in degrees of vascular attenuation before and after exercise(Baseline, 3 and 6 months follow up.)
- Change in amount of autofluorescence before and after exercise(Baseline, 3 and 6 months follow up.)
- Change in Goldmann Visual Field (GVF) scores(Baseline, 3 and 6 months follow up.)
- Change in retinal thickness before and after exercise(Baseline, 3 and 6 months follow up.)
- Change in retinal pigment epithelium (RPE) pigmentation before and after exercise(Baseline, 3 and 6 months follow up.)
- Change in the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) score(Baseline, 3 and 6 months follow up.)
研究者
Jiong Yan
Associate Professor
Emory University