Exercise and RP (AVAMC and Emory)
- Conditions
- Retinitis Pigmentosa
- Interventions
- Other: Spin exercise
- Registration Number
- NCT03381235
- Lead Sponsor
- Emory University
- Brief Summary
The purpose of this study is to look in humans at the relationship between moderate or little exercise and their potential effects on the retina in patients with Retinitis Pigmentosa (RP).
- Detailed Description
Human studies have shown that regular exercise may have positive effects on common degenerative diseases such as Alzheimer's disease. Exercise has also shown to improve conditions the eye such as macular degenerations, glaucoma, and cataracts. Mice with retinal degeneration which were exposed to exercise showed that it helped to slow the rate of degeneration. The purpose of this study is to look in humans at the relationship between moderate or little exercise and their potential effects on the retina in patients with Retinitis Pigmentosa (RP).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 4
- Visual field no less than 10 degrees;
- VA no worse than 20/200 in the better seeing eye.
- Not able to tolerate exercise due to an underlying medical condition.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Moderate exercise Spin exercise Subjects in the moderate exercise group will participate in Spin exercise designed by Dr. Nocera.
- Primary Outcome Measures
Name Time Method Change in Brain-Derived Neurotrophic Factor (BDNF) level before and after exercise Baseline, 3 and 6 months follow up. Sertum levels of BDNF in patients before and exercise program will be measured by testing blood
- Secondary Outcome Measures
Name Time Method Change in retina vasculature before and after exercise Baseline, 3 and 6 months follow up. Optical Coherence Tomography Angiography (OCTA) will serve as a tool to study retina vasculature, including choroidal, superficial and deep retinal vascular filling status and permeability, before and after exercise.
Change in degrees of vascular attenuation before and after exercise Baseline, 3 and 6 months follow up. Change in degrees of vascular attenuation will be evaluated using Optos wide-field fundus photography before and after exercise.
Change in amount of autofluorescence before and after exercise Baseline, 3 and 6 months follow up. Change in amount of autofluorescence will be evaluated using autofluorescent imaging before and after exercise.
Change in Goldmann Visual Field (GVF) scores Baseline, 3 and 6 months follow up. The final result of a GVF is a diagram "island of vision." The visual field is an island with a central peak and the altitude correlates with the visual sensitivity in a given location.
Change in retinal thickness before and after exercise Baseline, 3 and 6 months follow up. Change in retinal thickness will be evaluated using spectral-domain optical coherence tomography (SD-OCT) before and after exercise.
Change in retinal pigment epithelium (RPE) pigmentation before and after exercise Baseline, 3 and 6 months follow up. Change in retinal RPE pigmentation will be evaluated using Optos wide-field fundus photography before and after exercise.
Change in the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) score Baseline, 3 and 6 months follow up. NEI VFQ-25 measures the range of vision-related functioning experienced by persons. The 12 subscales in the NEI VFQ-25 are general vision, near vision, distance vision, driving, peripheral vision, color vision, ocular pain, general health, and vision-specific role difficulties, dependency, social function, and mental health. The subscale scores are calculated by summing the relevant items and transforming the raw scores into a 0 to 100 scale where higher scores indicate better functioning or well-being.
Trial Locations
- Locations (1)
Emory Clinic, Atlanta VA Medical Center
πΊπΈAtlanta, Georgia, United States