Evaluation of N-acetyl cysteine mouth wash as a new treatment approach for gingivitis

Phase 2

Completed

• Conditions: Gingivitis; Oral Health

• Registration Number: ISRCTN31352091
• Lead Sponsor: niversity of Science and Technology

Brief Summary

2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/30673864

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-02-22
• Study Completion: 2018-01-01
• Last Update Posted: 7 December 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Healthy gingiva with no evidence of periodontitis
2. Male and females aged between 18 to 28
3. Willing to participate and comply with the objectives of the study

Exclusion Criteria

1. Regular users of antiplaque rinses or the use of oral rinses for 30 days before baseline
2. Antibiotics intake within the previous 2 months
3. Smokers
4. Pregnancy or lactation
5. Systemic diseases or long term medications that influencing gingival conditions
6. Orthodontic appliance
7. Presence of detectable increased attachment loss
8. Chewing khat (flowering plant native to the Horn of Africa and the Arabian Peninsula)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bacteria in sub-gingival plaque is measured using bacteria samples from the participants analyzed using DNA sequencing at baseline and day 21 and 35.

Secondary Outcome Measures

Name	Time	Method
<br> For the preventative and treatment stages:<br> 1. Plaque is measured using an index scoring system from 0-3 at baseline and at day 7, 14, 21, 28 and 35<br> 2. Gingival index is measured using an index scoring system from 0-3 at baseline and at day 7, 14, 21, 28 and 35<br> 3. Papilla bleeding is measured using an index scoring system from 1-4 at baseline and at day 7, 14, 21, 28 and 35<br>