Analysis of Cutaneous Nerve Biopsies in Gastrointestinal Motility Disorders
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Presence of small fiber neuropathy in skin biopsy samples
研究概览
简要总结
This study is being done to evaluate cutaneous nerve biopsies from patients with refractory gastrointestinal motility disorders. The purpose of the study is to evaluate skin biopsies for signs of small fiber neuropathy in GI dysmotility patients, which may provide a better understanding of the underlying pathology of their condition. Specifically, identifying any small fiber neuropathy that may exist in the peripheral nervous system may help us to better understand the mechanism of presumed enteric neuropathy that may be involved in causing GI dysmotility.
详细描述
- Gather basic, clinical information and perform small 3-6mm skin biopsies.
- Identify characteristics of epidermal nerve fibers in patients with symptoms of gastrointestinal dysmotility
- To isolate skin-derived precursor cells from skin biopsies and test their ability to generate neurons in vitro and in immune-deficient mouse models.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Individual with a gastrointestinal motility disorder that has failed both clinical and surgical options for symptomatic management
排除标准
- •Child 17 years of age or younger
- •Individuals incapable of informed consent
- •Patient with diseased skin or on drugs which affect skin biology.
结局指标
主要结局
Presence of small fiber neuropathy in skin biopsy samples
时间窗: Only one biopsy but analysis may take one year.
Presence or absence of small fiber neuropathy obtained after the skin biopsy procedure.
次要结局
未报告次要终点