Analysis of Cutaneous Nerve Biopsies in Gastrointestinal Motility Disorders
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Small Fiber Neuropathy
- Sponsor
- Johns Hopkins University
- Locations
- 1
- Primary Endpoint
- Presence of small fiber neuropathy in skin biopsy samples
- Status
- Withdrawn
- Last Updated
- 2 years ago
Overview
Brief Summary
This study is being done to evaluate cutaneous nerve biopsies from patients with refractory gastrointestinal motility disorders. The purpose of the study is to evaluate skin biopsies for signs of small fiber neuropathy in GI dysmotility patients, which may provide a better understanding of the underlying pathology of their condition. Specifically, identifying any small fiber neuropathy that may exist in the peripheral nervous system may help us to better understand the mechanism of presumed enteric neuropathy that may be involved in causing GI dysmotility.
Detailed Description
1. Gather basic, clinical information and perform small 3-6mm skin biopsies. 2. Identify characteristics of epidermal nerve fibers in patients with symptoms of gastrointestinal dysmotility 3. To isolate skin-derived precursor cells from skin biopsies and test their ability to generate neurons in vitro and in immune-deficient mouse models.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Individual with a gastrointestinal motility disorder that has failed both clinical and surgical options for symptomatic management
Exclusion Criteria
- •Child 17 years of age or younger
- •Individuals incapable of informed consent
- •Patient with diseased skin or on drugs which affect skin biology.
Outcomes
Primary Outcomes
Presence of small fiber neuropathy in skin biopsy samples
Time Frame: Only one biopsy but analysis may take one year.
Presence or absence of small fiber neuropathy obtained after the skin biopsy procedure.