Correlation Between the 'Nine Holes Peg Test' Performance and the Triple Stimulation Technique Within a Group a Patients With Multiple Sclerosis

Not Applicable

Completed

• Conditions: Multiple Sclerosis
• Interventions: Other: Nine Hole Test; Device: Triple Stimulation Technique

• Registration Number: NCT02805634
• Lead Sponsor: Brugmann University Hospital

Brief Summary

The main goal of this study is to determine if the Triple Stimulation Technique (TST) can be correlated to performance in the manual dexterity 'nine holes peg' test, within a control group and a group of patients with multiple sclerosis.

TST (Triple stimulation technique) combines two techniques used in neurologic diagnosis: magnetic stimulation and electroneuromyography. It is based on the principle of two collisions between the descending central stimulation (magnetic stimulation) and the ascending peripheric stimulation. TST allows to better quantify central nervous system diseases. The abnormal amplitude registered by TST is proportional to the intensity of conduction disorders. The evaluation of these disorders is more precise than with the magnetic stimulation technique alone.

The Nine Hole Pegs technique is a simple manual dexterity test, commonly used in ergotherapy. The participant tries to place 9 pegs in a 9 holes perforated plate, and then tries to remove them as quickly as possible. The hand must stay in a depression within the plate, thereby insuring a constant distance between the hand and the pegs.

The nine hole peg will be realized first, and the triple stimulation examination performed after. The acquired data will be analyzed in order to find a correlation between the impairment level given by these two tests.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02-09
• Study First Submitted: 2016-03-31
• Study First Submitted QC: 2016-06-17
• Study First Posted: 2016-06-20
• Primary Completion: 2019-01-30
• Study Completion: 2019-01-30
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-16
• Last Update Posted: 2019-04-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Control group:

• No history of neurological disease
• No medicines intake that could disturb performance within the tests (psychotropic medications, sedatives, anti spastic and drugs acting on neuromuscular transmission).

Multiple sclerosis group

• Multiple sclerosis diagnose. Patients followed by Dr Dachy, within the CHU Brugmann Hospital.

Exclusion Criteria

• Persons carrying ferromagnetic material (implants, pacemaker).
• Epilepsy history.
• Patients who have had a head trauma with loss of consciousness and/or brain injury.
• Pregnant woman.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Multiple sclerosis	Nine Hole Test	Patients with multiple sclerosis, followed by Dr Dachy within the CHU Brugmann Hospital.
Multiple sclerosis	Triple Stimulation Technique	Patients with multiple sclerosis, followed by Dr Dachy within the CHU Brugmann Hospital.
Control group	Nine Hole Test	Control group without neurological pathology
Control group	Triple Stimulation Technique	Control group without neurological pathology

Primary Outcome Measures

Name	Time	Method
Amplitude ratio of the TST	during the TST (30 min)
Amplitude of the motor evoked potentials	during the TST (30 min)
Surface ratio of the TST	during the TST (30 min)
Nine Holes Peg test result	Baseline

Trial Locations

Locations (1)

CHU Brugmann; 🇧🇪 Brussels, Belgium