COMPARATIVE OBSERVATIONAL PROSPECTIVE RANDOMIZED STUDY TO DETERMINE THE EFFECT OF CLONIDINE AS AN ADJUNCT TO INDUCTION AGENTS IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING SURGERY

This Comparative Observational Prospective Randomized Study will be conducted in Department of Anesthesiology,D Y Patil University School of Medicine & Hospital, Nerul, Navi Mumbai.

1. Pre-operative evaluationHistory, PAST History, Clinical Examination, Routine investigations, Stress test, 2 D-ECHO, Coronary Angiography.2) On the day of surgery, patients will be examined. Volunteers will be allocated randomly with sealed envelop technique to 2 groups each containing forty patients each.• Group A (Clonidine) - Patients will receive i.v. clonidine as a pre-medication dose of 4 µg/kg in the OT.• Group B (Placebo) - Patients will receive IV 0.9%Normal Saline of the same volume in the OT.— NBM status will be confirmed. — Informed written consent will be taken.— Pre-operative vitals will be recorded in the form of baseline pulse and blood pressure.— After arriving in the OT monitors will be attached- Manual BP cuff, Pulse oximeter, Temperature Probe, Ecg Chest Leads.Cardio scope.Inspired air will be supplemented with oxygen at 5-6 liters/min— Vein will be canulated with appropriate intracath (16 G or 18 G) on the dorsum of hand.— Inj clonidine (4 µg/kg) will be given i.v. over 10 minutes.— Internal jugular vein will be canulated with triple lumen.— Radial artery will be canulated for intra-arterial blood pressure monitoring.— The patient will be induced with inj midazolam (0.1 mg/kg), inj fentanyl (5-10 µg/kg) and inj Vecuronium (0.1 mg/kg).The doses of Inj. propofol required will be given and any additional doses if required during the procedure will be noted.Maintenance: Sevoflurane (2% ) & Sedation Mixture (Inj. Fentanyl + Inj. Midazolam + Inj.Vecuronium)Rescue maintenance required with sevoflurane in the incremental doses 4%- 6% will be noted.The following Parameters will be Monitored intraoperatively: ECG, Pulse Oximetry, EtCO‚ IBP, CVP, Nasopharyngeal Temperature, Serial ABG, ACT.