Myocardial Stress Perfusion Imaging With Dual Source CT
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Per-Vessel Sensitivity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography.
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The investigators propose a novel technique using dual source multidetector computed tomography (DSCT) where information on both coronary anatomy and myocardial perfusion is obtained in a single scan. The investigators hypothesize that a coronary CTA protocol can be devised to obtain resting myocardial perfusion, myocardial perfusion after stress, and coronary anatomy. Hence, one diagnostic test will be able to detect the presence of coronary plaque as well as assess the functional significance of a stenosis.
Investigators
Brian Burns Ghoshhajra
Clinical Director, Cardiac CT and MRI, Department of Radiology
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •A prior adenosine or exercise stress SPECT exam with high likelihood of being referred to the cardiac catheterization laboratory for invasive angiogram
- •Age \> 40 years old
- •Able to comprehend and sign the consent form.
Exclusion Criteria
- •Acute coronary syndromes (unstable angina, non-ST elevation myocardial infarction, ST elevation myocardial infarction)
- •Unstable clinical conditions (i.e. hemodynamic instability, arrhythmias)
- •Premenopausal women who have a positive pregnancy test.
- •Serum Creatinine level ≥1.5 mg/dl as an indicator of renal insufficiency.
- •Known allergy to iodinated contrast agents
- •Atrial fibrillation
- •Critical aortic stenosis
- •Systolic blood pressure \< 90 mmHg
- •Advanced heart block
Outcomes
Primary Outcomes
Per-Vessel Sensitivity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography.
Time Frame: 18 months
The gold standard for abnormality by CTP is defined as a focal stenosis of \>50% at quantitative analysis of invasive coronary angiography images, when performed.
Per-Vessel Specificity of CTP in the Detection of Myocardial Perfusion Defects During Pharmacological Stress as Compared to Invasive Angiography.
Time Frame: 18 months
The gold standard for abnormality by CTP is defined as stenosis of 50% or more at quantitative analysis of invasive coronary angiography images, when performed.
Secondary Outcomes
- Per-Patient Correlation Between CTP and SPECT at Stress.(18 months)
- Per-Patient Correlation Between CTP and SPECT at Rest.(18 months)