Preoperative biliary drainage with metal stent in resectable periampullary cancer.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 102
研究概览
简要总结
Preoperative biliary drainage for cancer of the head of the pancreas. van der Gaag NA, Rauws EA, van Eijck CH, Bruno MJ, van der Harst E, Kubben FJ, Gerritsen JJ, Greve JW, Gerhards MF, de Hingh IH, Klinkenbijl JH, Nio CY, de Castro SM, Busch OR, van Gulik TM, Bossuyt PM, Gouma DJ. N Engl J Med. 2010 Jan 14;362(2):129-37. Therapeutic delay and survival after surgery for cancer of the pancreatic head with or without preoperative biliary drainage. Eshuis WJ, van der Gaag NA, Rauws EA, van Eijck CH, Bruno MJ, Kuipers EJ, Coene PP, Kubben FJ, Gerritsen JJ, Greve JW, Gerhards MF, de Hingh IH, Klinkenbijl JH, Nio CY, de Castro SM, Busch OR, van Gulik TM, Bossuyt PM, Gouma DJ. Ann Surg. 2010 Nov;252(5):840-9. Preoperative biliary drainage in patients with obstructive jaundice: history and current status. van der Gaag NA, Kloek JJ, de Castro SM, Busch OR, van Gulik TM, Gouma DJ. J Gastrointest Surg. 2009 Apr;13(4):814-20. Preoperative biliary drainage for periampullary tumors causing obstructive jaundice; DRainage vs. (direct) OPeration (DROP-trial). van der Gaag NA, de Castro SM, Rauws EA, Bruno MJ, van Eijck CH, Kuipers EJ, Gerritsen JJ, Rutten JP, Greve JW, Hesselink EJ, Klinkenbijl JH, Rinkes IH, Boerma D, Bonsing BA, van Laarhoven CJ, Kubben FJ, van der Harst E, Sosef MN, Bosscha K, de Hingh IH, Th de Wit L, van Delden OM, Busch OR, van Gulik TM, Bossuyt PM, Gouma DJ. BMC Surg. 2007 Mar 12;7:3. Delayed massive hemorrhage after pancreatic and biliary surgery: embolization or surgery? de Castro SM, Kuhlmann KF, Busch OR, van Delden OM, Lameris JS, van Gulik TM, Obertop H, Gouma DJ. Ann Surg. 2005 Jan;241(1):85-91. A meta-analysis on the efficacy of preoperative biliary drainage for tumors causing obstructive jaundice. Sewnath ME, Karsten TM, Prins MH, Rauws EJ, Obertop H, Gouma DJ. Ann Surg. 2002 Jul;236(1):17-27.
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •1. Clinical diagnosis of obstructive jaundice due to a pancreatic head or periampullary tumor;
- •2. A serum bilirubin level of > 40 µmol/l and < 250 µmol/l before inclusion;
排除标准
- •1. Age > 85 years or severe co-morbidity (Karnofsky <50%) and other contra indications for major surgery;
- •2. Cholangitis/infection;